PCBD1 and DIP2C

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		PCBD1	DIP2C
Description		pterin-4 alpha-carbinolamine dehydratase 1	disco interacting protein 2 homolog C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Exosome	Cellular_component
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	Molecular_function
	Biological Process	L-phenylalanine Metabolic Process Tetrahydrobiopterin Biosynthetic Process Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated	Biological_process
Pathways		Phenylalanine metabolism
Drugs		L-erythro-7,8-dihydrobiopterin
Diseases
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)	Blood metabolite levels ( 24816252) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Frontal pole volume ( 31530798) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Lateral ventricle temporal horn volume ( 31530798) Malaria ( 31844061) Psychosis in Alzheimer's disease ( 22005930) Uric acid levels ( 23703922)
Interacting Genes		54 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF1B HNF4A KANK2 KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 PICK1 POLR3A PSMA1 RBL2 RPS24 SAP30 SCMH1 SDCBP SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714	2 interacting genes: LARP4B PCBD1
Entrez ID		5092	22982
HPRD ID		00523	17200
Ensembl ID		ENSG00000166228	ENSG00000151240
Uniprot IDs		P61457	A0A0U1RQW6 Q86XV3 Q9Y2E4
PDB IDs
Enriched GO Terms of Interacting Partners?
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