PCBD1 and SCMH1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		PCBD1	SCMH1
Description		pterin-4 alpha-carbinolamine dehydratase 1	Scm polycomb group protein homolog 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Chromocenter
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	Chromatin Binding Protein Binding Histone Binding
	Biological Process	L-phenylalanine Metabolic Process Tetrahydrobiopterin Biosynthetic Process Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated	Chromatin Remodeling Spermatogenesis Anterior/posterior Pattern Specification Gene Silencing Negative Regulation Of Transcription, DNA-templated
Pathways		Phenylalanine metabolism
Drugs		L-erythro-7,8-dihydrobiopterin	Mercaptoethanol
Diseases
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)	Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Atrial fibrillation ( 30061737 29892015) General risk tolerance (MTAG) ( 30643258) Height ( 20881960 25282103 23563607 18391952) Hip circumference adjusted for BMI ( 34021172) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Rapid response to perioperative phenylephrine (change in mean arterial pressure) ( 33168928)
Interacting Genes		54 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF1B HNF4A KANK2 KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 PICK1 POLR3A PSMA1 RBL2 RPS24 SAP30 SCMH1 SDCBP SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714	22 interacting genes: EWSR1 FXR1 FXR2 GMNN HK1 HPCAL4 LYPLA2 LZTR1 MAGEA12 MAML3 MOB4 PCBD1 PHC1 PHC2 POLR2M SFMBT1 SFMBT2 TMEM11 TOB1 TSC1 UBQLN1 UBQLN4
Entrez ID		5092	22955
HPRD ID		00523	11540
Ensembl ID		ENSG00000166228	ENSG00000010803
Uniprot IDs		P61457	B3KMZ7 Q96GD3
PDB IDs			2P0K
Enriched GO Terms of Interacting Partners?
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