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PRKN and TUBA4A
Number of citations of the paper that reports this interaction (PubMedID
12716939
)
91
Data Source:
HPRD
(in vivo)
PRKN
TUBA4A
Description
parkin RBR E3 ubiquitin protein ligase
tubulin alpha 4a
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Postsynaptic Density
Aggresome
Nuclear Speck
SCF Ubiquitin Ligase Complex
Neuron Projection
Perinuclear Region Of Cytoplasm
Lewy Body
Presynapse
Mitochondrion-derived Vesicle
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Extracellular Region
Cytoplasm
Cytosol
Cytoskeleton
Microtubule
Microtubule Cytoskeleton
Extracellular Exosome
Molecular Function
G Protein-coupled Receptor Binding
Transcription Corepressor Activity
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Tubulin Binding
SH3 Domain Binding
Enzyme Binding
Kinase Binding
Protein Kinase Binding
PDZ Domain Binding
Hsp70 Protein Binding
Heat Shock Protein Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Histone Deacetylase Binding
Ubiquitin Binding
Phospholipase Binding
Protein-containing Complex Binding
Chaperone Binding
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Ubiquitin-specific Protease Binding
F-box Domain Binding
GTPase Activity
Structural Constituent Of Cytoskeleton
Protein Binding
GTP Binding
Protein Kinase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Mitochondrial Fission
Autophagy Of Mitochondrion
Mitophagy
Negative Regulation Of Protein Phosphorylation
Startle Response
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Response To Oxidative Stress
Mitochondrion Organization
Central Nervous System Development
Learning
Adult Locomotory Behavior
Proteasomal Protein Catabolic Process
Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Mitochondrial Fusion
Negative Regulation Of Mitochondrial Fusion
Regulation Of Mitochondrion Organization
Regulation Of Glucose Metabolic Process
Free Ubiquitin Chain Polymerization
Regulation Of Dopamine Secretion
Macroautophagy
Protein Ubiquitination
Protein Deubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Protein Destabilization
Positive Regulation Of Protein Binding
Negative Regulation Of Actin Filament Bundle Assembly
Regulation Of Lipid Transport
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Glucokinase Activity
Cellular Response To Unfolded Protein
Response To Endoplasmic Reticulum Stress
Synaptic Transmission, Glutamatergic
Protein K29-linked Ubiquitination
ERAD Pathway
Regulation Of Dopamine Metabolic Process
Norepinephrine Metabolic Process
Dopamine Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA Binding
Negative Regulation Of Neuron Apoptotic Process
Cellular Protein Catabolic Process
Protein K27-linked Ubiquitination
Negative Regulation By Host Of Viral Genome Replication
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Negative Regulation Of Insulin Secretion
Protein Stabilization
Positive Regulation Of Neurotransmitter Uptake
Dopamine Uptake Involved In Synaptic Transmission
Protein Autoubiquitination
Regulation Of Mitochondrial Membrane Potential
Zinc Ion Homeostasis
Negative Regulation Of Cell Death
Regulation Of Canonical Wnt Signaling Pathway
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Neuron Cellular Homeostasis
Protein K63-linked Ubiquitination
Protein Localization To Mitochondrion
Aggresome Assembly
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Response To Manganese Ion
Protein K6-linked Ubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Cellular Response To Toxic Substance
Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Mitochondrion To Lysosome Transport
Regulation Of Cellular Response To Oxidative Stress
Negative Regulation Of Neuron Death
Positive Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Negative Regulation Of Primary Amine Oxidase Activity
Positive Regulation Of Protein Linear Polyubiquitination
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Oxidative Stress-induced Cell Death
Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Dopamine
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Exosomal Secretion
Positive Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Dendrite Extension
Negative Regulation Of Spontaneous Neurotransmitter Secretion
Positive Regulation Of Retrograde Transport, Endosome To Golgi
Negative Regulation Of Intralumenal Vesicle Formation
Positive Regulation Of Protein Localization To Membrane
Amyloid Fibril Formation
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Pathways
PINK1-PRKN Mediated Mitophagy
Josephin domain DUBs
Aggrephagy
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Platelet degranulation
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Recycling pathway of L1
Hedgehog 'off' state
Cilium Assembly
Anchoring of the basal body to the plasma membrane
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Carboxyterminal post-translational modifications of tubulin
Carboxyterminal post-translational modifications of tubulin
HCMV Early Events
Assembly and cell surface presentation of NMDA receptors
Activation of AMPK downstream of NMDARs
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Sealing of the nuclear envelope (NE) by ESCRT-III
Kinesins
Drugs
Vincristine
Podofilox
Epothilone D
Patupilone
CYT997
Cabazitaxel
Phenethyl Isothiocyanate
Diseases
GWAS
Triglyceride levels in HIV infection (
33109212
)
Platelet distribution width (
32888494
27863252
)
Interacting Genes
130 interacting genes:
ADRM1
AIMP2
ARRB1
ARRB2
ATXN3
BAG5
BCL2L1
CASK
CASP1
CASP8
CCNB1
CCND1
CDC34
CDK5
CDKN1A
CHPF
COMMD1
CRX
CUL1
DLG1
DLX2
DNM1L
DYNLT1
DYRK1A
EPS15
FAF1
FAM120A
FBP1
FBXO7
FBXW7
GNL1
GPR37
GRIN2B
GRSF1
GTPBP4
HDAC6
HEXD
HSD17B10
IKBKG
LSG1
MDM2
MEOX1
MEOX2
MFN1
MFN2
MRPL13
MRPL19
MRPL45
NDUFA4L2
NEK2
NKRF
NQO1
PAFAH1B2
PDCD2
PICK1
PKM
PLK1
PRKAA2
PSMA1
PSMA7
PSMC1
PSMC2
PSMC5
PSMD4
PTPN5
PTTG1
RAB7A
RAC1
RAD1
RAD23A
RALY
RANBP2
RBCK1
REL
RGS2
RGS3
RHOT2
SEPTIN4
SEPTIN5
SF3B2
SF3B3
SIM2
SNCA
SNCAIP
STUB1
SUMO1
SYT11
TCF4
TENT5C
TOMM40
TOMM70
TP53
TRIP13
TUBA4A
TUBB
UBASH3A
UBASH3B
UBB
UBC
UBE2A
UBE2B
UBE2C
UBE2D1
UBE2D2
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2H
UBE2J1
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2O
UBE2R2
UBE2S
UBE2T
UBE2V1
UBE2Z
USP30
USP33
VDAC1
YWHAH
ZNF622
ZNF746
66 interacting genes:
ALPP
APC
ARHGAP1
ATP5MC3
B4GALT1
BCAR1
BRCA1
C4orf17
CALB2
CAPN2
CDK5R2
CXCR1
DPYSL2
EGFR
ENO2
EPB41
ETV6
FYN
GNAI2
GPHN
GRM7
HDAC6
HPCA
HSPH1
IL1RL1
LGALS2
LTA
MAGED1
MAP1A
MAP1LC3A
MAPT
MARK4
MYC
NCALD
NUPR1
OGT
PFDN4
PLK1
PRKN
RAB8B
RAC1
RACGAP1
RBM23
RTN4
S100A8
SIAH1
SIMC1
SIRT2
SKP1
SLC11A1
STARD13
STK16
SUMO2
SYK
TAOK2
TBCB
TBCE
TCP1
TCP11L2
TM4SF1
UCHL5
VAV1
VDAC1
WNT6
YWHAG
ZAP70
Entrez ID
5071
7277
HPRD ID
03967
01851
Ensembl ID
ENSG00000185345
ENSG00000127824
Uniprot IDs
O60260
X5DR79
P68366
PDB IDs
1IYF
2JMO
4BM9
4I1F
4I1H
5C1Z
5C23
5C9V
5N2W
5N38
5TR5
6GLC
6HUE
6N13
Enriched GO Terms of Interacting Partners
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