TUBA4A and SLC11A1

		TUBA4A	SLC11A1
Description		tubulin alpha 4a	solute carrier family 11 member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Extracellular Exosome	Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Phagocytic Vesicle Membrane Late Endosome Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Kinase Binding	Iron Ion Transmembrane Transporter Activity Manganese Ion Transmembrane Transporter Activity Cadmium Ion Transmembrane Transporter Activity Protein Homodimerization Activity Transition Metal Ion Transmembrane Transporter Activity Metal Ion:proton Antiporter Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle	Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production T Cell Proliferation Involved In Immune Response Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of T-helper 1 Type Immune Response Iron Ion Transport Manganese Ion Transport Cellular Cadmium Ion Homeostasis Cellular Iron Ion Homeostasis Phagocytosis Inflammatory Response Vacuolar Acidification Response To Bacterium Positive Regulation Of Gene Expression Nitrite Transport Antimicrobial Humoral Response Activation Of Protein Kinase Activity Response To Lipopolysaccharide Positive Regulation Of Interferon-gamma Production Response To Interferon-gamma Iron Ion Transmembrane Transport Wound Healing Macrophage Activation Defense Response To Bacterium Defense Response To Protozoan MHC Class II Biosynthetic Process Cell Redox Homeostasis Respiratory Burst Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation Of Peptide Antigen MRNA Stabilization Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Iron Ion Homeostasis Multicellular Organismal Iron Ion Homeostasis Cadmium Ion Transmembrane Transport Metal Ion Export Manganese Ion Transmembrane Transport L-arginine Transport
Pathways		Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins	ROS and RNS production in phagocytes Metal ion SLC transporters Neutrophil degranulation Ion influx/efflux at host-pathogen interface
Drugs		Vincristine Podofilox Epothilone D Patupilone CYT997 Cabazitaxel Phenethyl Isothiocyanate
Diseases
GWAS		Platelet distribution width ( 32888494 27863252)	Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)
Interacting Genes		66 interacting genes: ALPP APC ARHGAP1 ATP5MC3 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 CAPN2 CDK5R2 CXCR1 DPYSL2 EGFR ENO2 EPB41 ETV6 FYN GNAI2 GPHN GRM7 HDAC6 HPCA HSPH1 IL1RL1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD NUPR1 OGT PFDN4 PLK1 PRKN RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 SKP1 SLC11A1 STARD13 STK16 SUMO2 SYK TAOK2 TBCB TBCE TCP1 TCP11L2 TM4SF1 UCHL5 VAV1 VDAC1 WNT6 YWHAG ZAP70	1 interacting genes: TUBA4A
Entrez ID		7277	6556
HPRD ID		01851	02601
Ensembl ID		ENSG00000127824	ENSG00000018280
Uniprot IDs		P68366	P49279
PDB IDs
Enriched GO Terms of Interacting Partners?
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