P4HB and PLCXD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		P4HB	PLCXD3
Description		prolyl 4-hydroxylase subunit beta	phosphatidylinositol specific phospholipase C X domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Cytoskeleton Focal Adhesion External Side Of Plasma Membrane Procollagen-proline 4-dioxygenase Complex Lamellipodium Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Exosome	Cytoplasm Synapse
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Actin Binding Procollagen-proline 4-dioxygenase Activity Integrin Binding Protein Binding Protein-disulfide Reductase Activity Thiol Oxidase Activity Enzyme Binding Protein Heterodimerization Activity	Protein Binding Phosphoric Diester Hydrolase Activity
	Biological Process	Protein Folding Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Viral Entry Into Host Cell Cellular Response To Hypoxia Cellular Response To Interleukin-7 Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Signal Transduction Lipid Catabolic Process
Pathways		Collagen biosynthesis and modifying enzymes Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Interleukin-12 signaling Interleukin-23 signaling
Drugs		Zinc Ribostamycin Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Metabolite levels ( 23823483)
Interacting Genes		52 interacting genes: CD1D CHCHD2 CNNM3 COL10A1 COL1A1 COL1A2 CSNK2A2 CST2 EIF2S1 ENO1 ERN1 ERO1A ERO1B ESR1 FAM20C FAM71C FEZ1 FZD10 GRN HNRNPD ITGB3 KLHL42 KRTAP12-3 KRTAP13-2 KRTAP4-11 KRTAP5-9 KRTAP6-3 KRTAP9-8 LCE1B LCE2D LCE4A LCN2 LGALS9 LINC00839 LRFN4 NECTIN2 NOL4 NTM ODF1 OGT P4HA2 P4HA3 PLCXD3 PRNP PTN SUMO2 TG TGFB1 UBQLN1 VWF YWHAG ZNF69	3 interacting genes: MAGEA11 P4HB RICTOR
Entrez ID		5034	345557
HPRD ID		07181	17860
Ensembl ID		ENSG00000185624	ENSG00000182836
Uniprot IDs		A0A024R8S5 P07237	B3KXD1 Q63HM9
PDB IDs		1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1 4JU5 6I7S
Enriched GO Terms of Interacting Partners?
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