OXTR and THOC5

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		OXTR	THOC5
Description		oxytocin receptor	THO complex 5
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Microvillus Adherens Junction Apical Plasma Membrane	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Oxytocin Receptor Activity Vasopressin Receptor Activity Peptide Hormone Binding Peptide Binding	MRNA Binding Protein Binding
	Biological Process	Suckling Behavior Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Muscle Contraction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Lactation Memory Response To Xenobiotic Stimulus Positive Regulation Of Norepinephrine Secretion Telencephalon Development Sleep Positive Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Progesterone Response To Anoxia Response To Cytokine Social Behavior Response To Cocaine Maternal Behavior Sperm Ejaculation Eating Behavior Response To Peptide Hormone Estrous Cycle Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Digestive Tract Development Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Parturition Positive Regulation Of Penile Erection Negative Regulation Of Gastric Acid Secretion ERK1 And ERK2 Cascade Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Cold-induced Thermogenesis	MRNA Processing MRNA Export From Nucleus RNA Splicing Monocyte Differentiation Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus Primitive Hemopoiesis Negative Regulation Of DNA Damage Checkpoint
Pathways		Vasopressin-like receptors G alpha (q) signalling events	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs		Oxytocin Carbetocin Atosiban Relcovaptan
Diseases
GWAS		Caudate activity during reward ( 28927378) Chronotype ( 30696823) Depression and alcohol dependence ( 22064162) Liver fibrosis severity in HIV/hepatitis C co-infection ( 27339598) Morning person ( 30696823)	Apolipoprotein A1 levels ( 32203549) Carotid atherosclerosis in HIV infection ( 20009918) HDL cholesterol levels ( 32203549) Lipid traits ( 24023261)
Interacting Genes		18 interacting genes: ALAS1 ARRB2 ASH1L AVP CD81 CYFIP2 EMC10 FSCN1 GPRASP1 LCNL1 MVB12A OXT PSMA7 SIRT2 THOC5 TMEM161A TSPAN7 YIPF3	11 interacting genes: CSF1R CSNK2A1 HSPB1 LIG4 LSM3 NXF1 OXTR PPIL1 PRKCA THOC7 ZNF830
Entrez ID		5021	8563
HPRD ID		01328	16650
Ensembl ID		ENSG00000180914	ENSG00000100296
Uniprot IDs		B2R9L7 P30559	A0A024R1D6 Q13769
PDB IDs		6TPK	7APK
Enriched GO Terms of Interacting Partners?
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