NTRK3 and NTF3

Number of citations of the paper that reports this interaction (PubMedID 9973222)
24

Data Source:
HPRD (in vivo, in vitro)

		NTRK3	NTF3
Description		neurotrophic receptor tyrosine kinase 3	neurotrophin 3
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Axon Receptor Complex Glutamatergic Synapse Integral Component Of Postsynaptic Membrane	Extracellular Region Extracellular Space Synaptic Vesicle Axon Dendrite
	Molecular Function	P53 Binding Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Neurotrophin Binding	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity Chemoattractant Activity
	Biological Process	Neuron Migration Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Heart Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Kinase Activity Neurotrophin Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Response To Ethanol Ephrin Receptor Signaling Pathway Neuron Fate Specification Response To Axon Injury Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Positive Chemotaxis Response To Corticosterone Regulation Of Protein Kinase B Signaling Negative Regulation Of Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cochlea Development Activation Of GTPase Activity Regulation Of Postsynaptic Density Assembly Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Actin Cytoskeleton Reorganization	Positive Regulation Of Receptor Internalization Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Nervous System Development Peripheral Nervous System Development Memory Positive Regulation Of Cell Population Proliferation Nerve Development Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Nerve Growth Factor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Neuron Projection Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Modulation Of Chemical Synaptic Transmission Positive Chemotaxis Induction Of Positive Chemotaxis Activation Of GTPase Activity Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Receptor-type tyrosine-protein phosphatases NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K NTRK3 as a dependence receptor	NTF3 activates NTRK2 (TRKB) signaling NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K
Drugs		Entrectinib Fostamatinib Larotrectinib Pralsetinib
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Gaucher disease severity ( 22388998) General risk tolerance (MTAG) ( 30643258)	Blood protein levels ( 30072576) Insomnia ( 29520036)
Interacting Genes		28 interacting genes: APP BEX3 DOK5 DOK6 DYNLL1 ERBB2 FRS2 HEY1 HTR2A IRAK1 IRAK3 JUN KIDINS220 KPNA4 MAPK1 MAPK3 NELFB NGFR NSD1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SORT1 SQSTM1 WDR13	7 interacting genes: BDNF LRP1 MEOX2 NTRK1 NTRK2 NTRK3 SORT1
Entrez ID		4916	4908
HPRD ID		01870	01219
Ensembl ID		ENSG00000140538	ENSG00000185652
Uniprot IDs		B7Z7U4 O95193 Q16288 Q96CY4 X5D2R1 X5D7M5 X5DNW6	P20783
PDB IDs		1WWC 3V5Q 4YMJ 6KZC 6KZD	1B8K 1BND 1NT3 3BUK
Enriched GO Terms of Interacting Partners?
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