NTRK3 and IRAK1

Number of citations of the paper that reports this interaction (PubMedID 12034707)
23

Data Source:
HPRD (in vivo)

		NTRK3	IRAK1
Description		neurotrophic receptor tyrosine kinase 3	interleukin 1 receptor associated kinase 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Axon Receptor Complex Glutamatergic Synapse Integral Component Of Postsynaptic Membrane	Nucleus Nucleoplasm Cytoplasm Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Protein-containing Complex
	Molecular Function	P53 Binding Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Neurotrophin Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity
	Biological Process	Neuron Migration Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Heart Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Kinase Activity Neurotrophin Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Response To Ethanol Ephrin Receptor Signaling Pathway Neuron Fate Specification Response To Axon Injury Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Positive Chemotaxis Response To Corticosterone Regulation Of Protein Kinase B Signaling Negative Regulation Of Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cochlea Development Activation Of GTPase Activity Regulation Of Postsynaptic Density Assembly Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Actin Cytoskeleton Reorganization	Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Aging Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Innate Immune Response Protein Autophosphorylation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Type I Interferon Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		Receptor-type tyrosine-protein phosphatases NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K NTRK3 as a dependence receptor	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Transcriptional Regulation by MECP2 Interleukin-1 signaling IRAK1 recruits IKK complex TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs		Entrectinib Fostamatinib Larotrectinib Pralsetinib	Fostamatinib
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Gaucher disease severity ( 22388998) General risk tolerance (MTAG) ( 30643258)	Celiac disease ( 22057235) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Rheumatoid arthritis ( 32723749 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 26606652 33272962 26663301 26502338 19838195)
Interacting Genes		28 interacting genes: APP BEX3 DOK5 DOK6 DYNLL1 ERBB2 FRS2 HEY1 HTR2A IRAK1 IRAK3 JUN KIDINS220 KPNA4 MAPK1 MAPK3 NELFB NGFR NSD1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SORT1 SQSTM1 WDR13	59 interacting genes: AKT1 BCL10 BTK CCDC47 FADD GDI1 H3-4 HRAS HSP90AA1 IDS IKBKG IL1RAP IRAK1BP1 IRAK2 IRAK3 IRAK4 IRF4 IRF7 ITGAM JADE2 JUN LDHD MAGEA2 MAP3K7 MAPK14 MAPK8 MBP MYD88 NLRP12 NMRK2 NTRK3 OPTN PELI1 PELI2 PELI3 PPP3CB PRKCI PRKCZ RAB31 RASSF2 RIPK2 RPF1 SIGIRR SQSTM1 STAT3 STING1 SUMO1 TAB2 TICAM2 TIFA TIRAP TLR2 TLR4 TOLLIP TRAF4 TRAF6 TRIM32 UBE2E3 YTHDC2
Entrez ID		4916	3654
HPRD ID		01870	02235
Ensembl ID		ENSG00000140538	ENSG00000184216
Uniprot IDs		B7Z7U4 O95193 Q16288 Q96CY4 X5D2R1 X5D7M5 X5DNW6	D3YTB5 P51617
PDB IDs		1WWC 3V5Q 4YMJ 6KZC 6KZD	6BFN
Enriched GO Terms of Interacting Partners?
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