NEDD8 and CUL1

Number of citations of the paper that reports this interaction (PubMedID 10713156)
146

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		NEDD8	CUL1
Description		NEDD8 ubiquitin like modifier	cullin 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Nucleoplasm Cytosol Plasma Membrane SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Protein Tag Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Localization Anatomical Structure Morphogenesis Response To Organic Cyclic Compound Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Neddylation	G1/S Transition Of Mitotic Cell Cycle Protein Monoubiquitination Cell Population Proliferation Animal Organ Morphogenesis Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Intrinsic Apoptotic Signaling Pathway
Pathways		TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport	Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Regulation of BACH1 activity Nuclear events stimulated by ALK signaling in cancer Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Metabolite levels ( 23823483) Uterine fibroid size (maximum volume) ( 30196971)
Interacting Genes		43 interacting genes: AHR ARIH2 ATE1 ATXN3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNMT3B GARS1 GHR HGS HIF1A HSPA4 N4BP1 NAE1 NUB1 OTUB1 OTUD5 PARP1 POLI PSMA6 PSMD4 PTK2 RAD23A SENP8 SMURF1 TP53 UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2	57 interacting genes: BTRC CAND1 CDC34 CDCA3 CDK9 CDKN1B CENPE CENPW CFLAR CHEK1 CHUK CKS1B COMMD1 COPS5 COPS6 COPS8 DLEU2 E2F1 FBH1 FBXO25 FBXW11 FBXW2 FBXW4 FBXW7 GHR GPS1 HIPK2 KHNYN NEDD8 NFKBIA NFKBIB NFKBIE NLK NLRP3 NR1D2 PPP1CA PRKN PRPF40A PSMB4 PSMD4 PTTG1 RAC2 RANBP2 RBX1 RICTOR RNF7 SENP8 SKP1 SKP2 SMAD3 THRA TRIM21 UBC UBE2E3 UBE2F UBE2M ZC3HC1
Entrez ID		4738	8454
HPRD ID		04412	04389
Ensembl ID		ENSG00000129559	ENSG00000055130
Uniprot IDs		Q15843	A0A090N7U0 B3KTW0 Q13616
PDB IDs		1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU 7B5L 7B5N	1LDJ 1LDK 1U6G 3RTR 3TDU 3TDZ 4F52 4P5O 5V89 6TTU 6WCQ 7B5L 7B5M 7B5N 7B5R 7B5S
Enriched GO Terms of Interacting Partners?
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