NEDD8 and OTUD5

Number of citations of the paper that reports this interaction (PubMedID 30659753)
6

Data Source:
BioGRID (pull down)

		NEDD8	OTUD5
Description		NEDD8 ubiquitin like modifier	OTU deubiquitinase 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Cytosol
	Molecular Function	Protein Binding Protein Tag Ubiquitin Protein Ligase Binding	Thiol-dependent Deubiquitinase Lys63-specific Deubiquitinase Activity Deubiquitinase Activity Lys48-specific Deubiquitinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Localization Anatomical Structure Morphogenesis Response To Organic Cyclic Compound Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Neddylation	Protein Deubiquitination Negative Regulation Of Type I Interferon Production Response To Lipopolysaccharide Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling
Pathways		TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport	Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		43 interacting genes: AHR ARIH2 ATE1 ATXN3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNMT3B GARS1 GHR HGS HIF1A HSPA4 N4BP1 NAE1 NUB1 OTUB1 OTUD5 PARP1 POLI PSMA6 PSMD4 PTK2 RAD23A SENP8 SMURF1 TP53 UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2	12 interacting genes: ARPC3 NEDD8 NONO PDCD5 POLR2A POLR2B POLR2C SUB1 TP53 TRAF3 UBC UBR5
Entrez ID		4738	55593
HPRD ID		04412	06488
Ensembl ID		ENSG00000129559	ENSG00000068308
Uniprot IDs		Q15843	A0A024QZ09 Q96G74
PDB IDs		1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU 7B5L 7B5N	3PFY 3TMO 3TMP
Enriched GO Terms of Interacting Partners?
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