NCL and DUX4

Number of citations of the paper that reports this interaction (PubMedID 26816005)
15

Data Source:
BioGRID (pull down)

		NCL	DUX4
Description		nucleolin	double homeobox 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Chromosome Nucleolus Cell Cortex Membrane Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Golgi Apparatus Cytosol Nuclear Membrane
	Molecular Function	RNA Binding Protein Binding Protein C-terminus Binding Telomeric DNA Binding Identical Protein Binding DNA Topoisomerase Binding MRNA 5'-UTR Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Leukemia Inhibitory Factor	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 23728934) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Eating disorders (purging via substances) ( 23568457) Hearing loss in noise exposure ( 26121033) Height ( 31562340) Hip index ( 34021172)
Interacting Genes		57 interacting genes: ADAP1 ADAP2 CD3E CDK1 CDKN2A CLK1 CSNK2A1 CSNK2A2 DUX4 ERG ESR1 ETS1 FMR1 GRB2 GZF1 GZMA H1-2 H2AC20 H2AX H2BC21 H3-4 HMGA1 IL7R LINC01554 MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 OGT PARP1 PPARGC1A PPM1D PRKCZ PRMT5 PTGS1 RAD51 S100A11 SREK1 SRPK2 SSB STAU1 SUMO2 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZFP41 ZNF689	124 interacting genes: ACTG1 AP2A1 AP3D1 ARF1 ATP5F1C C1QBP CAND1 CAPN2 CAVIN1 CCT6A CLTC COPA CSE1L DDX21 DDX3X DDX5 DES DHX30 DHX36 DHX9 DYNC1H1 EEF2 EFTUD2 ENO1 EP300 EPRS1 FASN FLNA GAPDH GARS1 HMGB1 HNRNPA1L2 HNRNPF HNRNPH1 HNRNPK HNRNPM HNRNPU HSPD1 IARS1 IGF2BP1 IGF2BP3 ILF3 IQGAP1 LDHA MARS1 MCM7 MTHFD1 MYBBP1A MYH10 MYH9 MYL6B NCL NPM1 PABPC1 PABPC4 PARP1 PFAS PKM PPP2R1A PRKDC PRPF8 RAN RPL10 RPL10A RPL12 RPL13 RPL15 RPL17 RPL18 RPL19 RPL21 RPL22 RPL23 RPL23A RPL27A RPL3 RPL30 RPL31 RPL35 RPL36 RPL4 RPL6 RPL7 RPL7A RPL8 RPL9 RPN1 RPS10 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS2 RPS20 RPS24 RPS25 RPS3 RPS3A RPS4X RPS6 RPS7 RPS8 RPS9 SF3B1 SHMT2 SLC25A3 SLC25A5 SLC25A6 SNRNP200 SRSF3 TCP1 TUBB TUBB2A TUBB3 TUBB6 VDAC1 VDAC2 VIM XRCC5 XRCC6 YBX1
Entrez ID		4691	100288687
HPRD ID		01245
Ensembl ID		ENSG00000115053	ENSG00000260596
Uniprot IDs		B3KM80 P19338	C3U3A0 Q9UBX2
PDB IDs		2FC8 2FC9 2KRR	5Z2S 5Z2T 5Z6Z 5ZFW 5ZFY 5ZFZ 6A8R 6DFY 6E8C 6U81 6U82
Enriched GO Terms of Interacting Partners?
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