NBL1 and NCS1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		NBL1	NCS1
Description		NBL1, DAN family BMP antagonist	neuronal calcium sensor 1
Image
GO Annotations	Cellular Component	Extracellular Space	Cytoplasm Golgi Apparatus Plasma Membrane Postsynaptic Density Dendrite Dense Core Granule Intracellular Membrane-bounded Organelle Calyx Of Held Perinuclear Region Of Cytoplasm Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Protein Binding Morphogen Activity BMP Binding Identical Protein Binding Receptor Ligand Activity	Magnesium Ion Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Kinase Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Signal Transduction Nervous System Development Animal Organ Morphogenesis Negative Regulation Of BMP Signaling Pathway Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Positive Regulation Of Neuron Differentiation Determination Of Dorsal Identity Neuron Projection Morphogenesis Negative Regulation Of Monocyte Chemotaxis	Regulation Of Neuron Projection Development Positive Regulation Of Exocytosis Phosphatidylinositol-mediated Signaling Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis
Pathways
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Blood protein levels ( 30072576) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Bronchopulmonary dysplasia in preterm infants ( 30113228) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Lymphocyte counts ( 32888494) Serum thyroid-stimulating hormone levels ( 24852370) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Alzheimer's disease (cognitive decline) ( 23535033) Tuberculosis ( 30713548)
Interacting Genes		14 interacting genes: BAG6 DPEP2NB HPCAL1 KRTAP11-1 LRIG1 MEOX2 MRPL12 NCALD NCS1 PLA2G2F SLPI UBQLN1 UBQLN2 ZMIZ2	28 interacting genes: C1QTNF2 CDSN CEP89 CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 EXOSC2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10
Entrez ID		4681	23413
HPRD ID		09001	04500
Ensembl ID		ENSG00000158747	ENSG00000107130
Uniprot IDs		A0A087WTY6 P41271	A0A024R8B2 P62166
PDB IDs		4X1J 4YU8	1G8I 2LCP 4GUK 5O9S 6QI4
Enriched GO Terms of Interacting Partners?
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