JUP and NFKBIE

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		JUP	NFKBIE
Description		junction plakoglobin	NFKB inhibitor epsilon
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen	Fibrillar Center Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Homodimerization Activity Protein-containing Complex Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytoskeletal Protein-membrane Anchor Activity	Protein Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Blood Vessel Endothelial Cell Migration Skin Development Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Positive Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Cytoplasmic Sequestering Of Transcription Factor
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle	Activation of NF-kappaB in B cells
Drugs		Zinc Zinc acetate
Diseases
GWAS		Heel bone mineral density ( 30598549 28869591) Major depressive disorder x sex interaction ( 34099189)	Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Rheumatoid arthritis ( 32723749 30423114 22446963 23028356 24390342)
Interacting Genes		53 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNA3 CTNNBIP1 CTNND1 DDX6 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 ERBB3 FER FHL2 FYN HSP90AA1 MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PRR35 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 RSPH14 SRC TBP TCF4 TCF7L2 YJU2B ZFYVE9	21 interacting genes: ANKHD1 BYSL C1QBP COG7 CUL1 GUCA1B HDAC4 HDAC5 IL1A JUP KBTBD7 NCOR2 NFKB1 NFKB2 NPR3 PEX6 POLH PPP6C REL RELA SKP1
Entrez ID		3728	4794
HPRD ID		01414	05181
Ensembl ID		ENSG00000173801	ENSG00000146232
Uniprot IDs		A0A0S2Z487 P14923	A0A024RD24 O00221 Q7LC14 Q96F31
PDB IDs		3IFQ
Enriched GO Terms of Interacting Partners?
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