JUP and DSC2

Number of citations of the paper that reports this interaction (PubMedID 9443898)
28

Data Source:
HPRD (in vivo)

		JUP	DSC2
Description		junction plakoglobin	desmocollin 2
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen	Cornified Envelope Plasma Membrane Cell-cell Junction Intercalated Disc Integral Component Of Membrane Desmosome Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Homodimerization Activity Protein-containing Complex Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytoskeletal Protein-membrane Anchor Activity	Calcium Ion Binding Protein Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Blood Vessel Endothelial Cell Migration Skin Development Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Positive Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle	Keratinization Formation of the cornified envelope
Drugs		Zinc Zinc acetate
Diseases
GWAS		Heel bone mineral density ( 30598549 28869591) Major depressive disorder x sex interaction ( 34099189)	Blood protein levels ( 30072576 29875488) Bronchopulmonary dysplasia ( 23897914) Metabolite levels ( 23823483) Response to immune checkpoint inhibitors in melanoma (immune-related adverse events) ( 33409738)
Interacting Genes		53 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNA3 CTNNBIP1 CTNND1 DDX6 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 ERBB3 FER FHL2 FYN HSP90AA1 MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PRR35 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 RSPH14 SRC TBP TCF4 TCF7L2 YJU2B ZFYVE9	12 interacting genes: CDC6 CELF4 CLK1 DSC3 DSG1 DSG2 FHOD3 ITSN1 JUP PKP2 PKP3 RO60
Entrez ID		3728	1824
HPRD ID		01414	00512
Ensembl ID		ENSG00000173801	ENSG00000134755
Uniprot IDs		A0A0S2Z487 P14923	A0A3B3ISU0 Q02487
PDB IDs		3IFQ	5ERP 5J5J 7A7D
Enriched GO Terms of Interacting Partners?
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