APOC4 and THBD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		APOC4	THBD
Description		apolipoprotein C4	thrombomodulin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Very-low-density Lipoprotein Particle High-density Lipoprotein Particle	Extracellular Space Vacuolar Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Apicolateral Plasma Membrane
	Molecular Function	Lipid Transporter Activity Protein Binding	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding Signaling Receptor Activity
	Biological Process	Lipid Metabolic Process Lipid Transport Positive Regulation Of Sequestering Of Triglyceride Triglyceride Homeostasis	Female Pregnancy Blood Coagulation Response To X-ray Negative Regulation Of Platelet Activation Negative Regulation Of Blood Coagulation Response To Lipopolysaccharide Response To CAMP Negative Regulation Of Fibrinolysis
Pathways		VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall
Drugs			Drotrecogin alfa Ibuprofen Dexibuprofen
Diseases
GWAS		Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488 28240269) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) HDL cholesterol levels ( 32203549) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 18802019 18193043 18193044 20864672 19060906) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Quantitative traits ( 19197348) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Blood protein levels in cardiovascular risk ( 28369058) Lung function (FVC) in asthma ( 32989782) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Venous thromboembolism ( 26888256)
Interacting Genes		25 interacting genes: APOE APOL2 BCL2L2 DIABLO GAD2 GSDMA IFI27 LETMD1 MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 UBQLN1 UBQLN2 VKORC1	31 interacting genes: AIG1 APOC2 APOC4 AQP6 CD79A CIDEB CYBC1 EBP ERGIC3 F2 FAM209A FCER1G GPX8 KIR2DL3 LMNA MMGT1 MTIF3 MUC1 PDZK1IP1 PF4 PHF24 PROC PSENEN RHBDD2 SERPINA5 SLC19A3 SLC35C2 TMEM14B TMEM35A TMEM86B TMX2
Entrez ID		346	7056
HPRD ID		02848	01764
Ensembl ID		ENSG00000267467	ENSG00000178726
Uniprot IDs		P55056	P07204
PDB IDs			1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS 5TO3
Enriched GO Terms of Interacting Partners?
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