APOC4 and GSDMA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		APOC4	GSDMA
Description		apolipoprotein C4	gasdermin A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Very-low-density Lipoprotein Particle High-density Lipoprotein Particle	Cytosol Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Lipid Transporter Activity Protein Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Positive Regulation Of Sequestering Of Triglyceride Triglyceride Homeostasis	Apoptotic Process Defense Response To Bacterium Pyroptosis
Pathways		VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488 28240269) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) HDL cholesterol levels ( 32203549) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 18802019 18193043 18193044 20864672 19060906) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Quantitative traits ( 19197348) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Asthma ( 31959851 20860503 31619474 29785011) Asthma (childhood onset) ( 24241537) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 28067908) Hematological parameters ( 19820697) Inflammatory bowel disease ( 28067908 23128233) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Refractive error ( 32231278) Systemic sclerosis ( 28314753) Ulcerative colitis ( 28067908) White blood cell count ( 22037903 20139978 21738480)
Interacting Genes		25 interacting genes: APOE APOL2 BCL2L2 DIABLO GAD2 GSDMA IFI27 LETMD1 MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 UBQLN1 UBQLN2 VKORC1	4 interacting genes: APOC1 APOC2 APOC4 CISD3
Entrez ID		346	284110
HPRD ID		02848	17081
Ensembl ID		ENSG00000267467	ENSG00000167914
Uniprot IDs		P55056	Q96QA5
PDB IDs
Enriched GO Terms of Interacting Partners?
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