ICAM3 and PRKCQ

Number of citations of the paper that reports this interaction (PubMedID 9268366)
3

Data Source:
HPRD (in vivo, in vitro)

		ICAM3	PRKCQ
Description		intercellular adhesion molecule 3	protein kinase C theta
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome	Immunological Synapse Cytosol Plasma Membrane Aggresome Centriolar Satellite
	Molecular Function	Signaling Receptor Binding Integrin Binding Protein Binding	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Phagocytosis Cell Adhesion Cell-cell Adhesion	Regulation Of Cell Growth Immune System Process Regulation Of Transcription, DNA-templated Membrane Protein Ectodomain Proteolysis Inflammatory Response Axon Guidance Peptidyl-serine Phosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Telomerase Activity Cell Chemotaxis Negative Regulation Of T Cell Apoptotic Process Regulation Of Platelet Aggregation Positive Regulation Of Telomere Capping Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 2 Cell Activation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling	Apoptotic cleavage of cellular proteins Effects of PIP2 hydrolysis Downstream TCR signaling Inactivation, recovery and regulation of the phototransduction cascade FCERI mediated NF-kB activation FCERI mediated NF-kB activation Netrin-1 signaling G alpha (z) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RAS processing
Drugs			Tamoxifen Staurosporine Phosphonothreonine Dexfosfoserine Fostamatinib
Diseases
GWAS		Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)	Asthma ( 31959851 30929738) Asthma (bronchodilator response) ( 23508266) Asthma (childhood onset) ( 31036433 30929738) Autoimmune traits (pleiotropy) ( 30572963) Body mass index in asthmatics ( 23517042) Celiac disease ( 22057235 24999842) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic pain ( 33685280) Crohn's disease ( 28067908) Factor VII activity ( 30642921) Immune response to smallpox vaccine (IL-6) ( 22542470) Medication use (thyroid preparations) ( 31015401) Rheumatoid arthritis ( 30423114 18794853 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 19430480 18978792)
Interacting Genes		29 interacting genes: APP BRICD5 C3 CALR CD209 CLDN19 CLDN4 CLEC4M EDDM3B EPOR EZR GCC2 ITGAD ITGAL ITGB2 MSN NINJ2 PRKCQ PRLR RFX2 RPL18 SEC22A SFTPC SMCO4 SMIM1 TNFRSF1B TSPO USF2 ZBTB16	28 interacting genes: AKT1 BTK CARD11 CASP3 CBL CHUK CISH FYN GATA3 GLRX3 GRM5 HABP4 ICAM3 IKBKB IKBKG IRS1 LCK LYN MARK3 MSN RASGRP3 SELL STK39 TAL1 VAV1 WIPF1 YWHAG YWHAQ
Entrez ID		3385	5588
HPRD ID		00889	02710
Ensembl ID		ENSG00000076662	ENSG00000065675
Uniprot IDs		A0A024R7C1 K7ERN2 P32942	Q04759
PDB IDs		1T0P	1XJD 2ENJ 2ENN 2ENZ 2JED 4Q9Z 4RA5 5F9E
Enriched GO Terms of Interacting Partners?
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