BIRC5 and AKAP6

		BIRC5	AKAP6
Description		baculoviral IAP repeat containing 5	A-kinase anchoring protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule Midbody Chromosome Passenger Complex	Nuclear Envelope Cytoplasm Caveola Junctional Sarcoplasmic Reticulum Membrane Intercalated Disc Sarcoplasmic Reticulum T-tubule Nuclear Membrane Calcium Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding Small GTPase Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Chaperone Binding	Protein Binding Adenylate Cyclase Binding Protein Kinase A Regulatory Subunit Binding Protein-membrane Adaptor Activity Transmembrane Transporter Binding Protein Kinase A Binding Molecular Adaptor Activity
	Biological Process	Protein Phosphorylation Apoptotic Process Cell Cycle Chromosome Segregation Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Protein-containing Complex Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Cell Division Regulation Of Cell Cycle	Action Potential Protein Targeting Regulation Of Protein Kinase A Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum CAMP-mediated Signaling Positive Regulation Of Cell Growth Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Membrane Repolarization Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To CAMP Cellular Response To Cytokine Stimulus Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation
Drugs		Reserpine Berberine LY2181308
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Periodontitis (Mean PAL) ( 24024966)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Anorexia nervosa ( 21079607) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 29273806) Atrial fibrillation ( 30061737 29892015) Bipolar disorder ( 31043756) Body mass index ( 28892062 25673413 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Coffee consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 25644384) Creatine kinase levels ( 29403010) Diisocyanate-induced asthma ( 25918132) Economic and political preferences (environmentalism) ( 22566634) Fasting blood insulin (BMI interaction) ( 22581228) General cognitive ability ( 29844566) Glioma ( 28346443) HDL cholesterol levels ( 32203549) Intelligence (MTAG) ( 29326435) Night sleep phenotypes ( 27126917) Non-glioblastoma glioma ( 28346443) Photic sneeze reflex ( 27182965) PR interval ( 32439900) Refractive error ( 32231278) Schizophrenia ( 28991256 30285260) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Type 2 diabetes ( 30297969) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Walking pace ( 33128006)
Interacting Genes		34 interacting genes: AANAT AKAP6 AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CCDC85B CDCA8 CDK1 CDK4 CSNK1D DIABLO EVI5 FASN FBXL7 GCGR H3-4 H3C14 HSP90AA1 INCENP KCNJ6 NNMT OGT RAN RASA1 SSH2 TLE3 XIAP XPO1	19 interacting genes: BIRC5 CALM1 CDC5L DISC1 DTNBP1 FUT3 GEMIN2 MAGEA6 PABPN1 PDE4D PGC PPP2CA PRKAR2A PTPRM RYR1 RYR2 SLC8A1 SPTSSA SSTR1
Entrez ID		332	9472
HPRD ID		04520	05257
Ensembl ID		ENSG00000089685	ENSG00000151320
Uniprot IDs		A0A0B4J1S3 H3BLT4 O15392	B2RP22 Q13023
PDB IDs		1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N 6SHO 6YIE 6YIF 6YIH
Enriched GO Terms of Interacting Partners?
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