BIRC5 and EVI5

Number of citations of the paper that reports this interaction (PubMedID 16764853)
9

Data Source:
BioGRID (pull down)

		BIRC5	EVI5
Description		baculoviral IAP repeat containing 5	ecotropic viral integration site 5
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule Midbody Chromosome Passenger Complex	Nucleus Microtubule Organizing Center Spindle Cytosol
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding Small GTPase Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Chaperone Binding	GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Cell Cycle Chromosome Segregation Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Protein-containing Complex Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Cell Division Regulation Of Cell Cycle	Intracellular Protein Transport Cell Cycle Retrograde Transport, Endosome To Golgi Positive Regulation Of GTPase Activity Cell Division Activation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation
Drugs		Reserpine Berberine LY2181308
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Periodontitis (Mean PAL) ( 24024966)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Apolipoprotein B levels ( 32203549) Asthma or allergic disease (pleiotropy) ( 29785011) Body fat percentage and LDL-C (pairwise) ( 33619380) Cholesterol, total ( 24097068 25961943 20686565) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) LDL cholesterol ( 30275531 25961943) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731 33339817) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244 24076602 19525955 21833088 27386562) Systemic lupus erythematosus ( 28714469) Total cholesterol levels ( 28334899 33339817 30275531)
Interacting Genes		34 interacting genes: AANAT AKAP6 AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CCDC85B CDCA8 CDK1 CDK4 CSNK1D DIABLO EVI5 FASN FBXL7 GCGR H3-4 H3C14 HSP90AA1 INCENP KCNJ6 NNMT OGT RAN RASA1 SSH2 TLE3 XIAP XPO1	22 interacting genes: ARL4A AURKB BIRC5 CCDC185 CEP19 CSNK1D ELOA FAM161A FBXO5 IMP3 INCENP LENG1 LMO1 MB21D2 MCRS1 MORF4L2 PRPF31 REP15 STX3 TCEANC TNFAIP8L1 ZNF446
Entrez ID		332	7813
HPRD ID		04520	04249
Ensembl ID		ENSG00000089685	ENSG00000067208
Uniprot IDs		A0A0B4J1S3 H3BLT4 O15392	O60447 Q59FE7
PDB IDs		1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N 6SHO 6YIE 6YIF 6YIH
Enriched GO Terms of Interacting Partners?
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