HSD17B3 and MCC

Number of citations of the paper that reports this interaction (PubMedID 24412244)
2

Data Source:
BioGRID (two hybrid)

		HSD17B3	MCC
Description		hydroxysteroid 17-beta dehydrogenase 3	MCC regulator of WNT signaling pathway
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Lamellipodium Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Oxidoreductase Activity Testosterone Dehydrogenase [NAD(P)] Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Steroid Biosynthetic Process Androgen Biosynthetic Process Male Genitalia Development Testosterone Biosynthetic Process	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Androgen biosynthesis Synthesis of very long-chain fatty acyl-CoAs
Drugs		NADH
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 26252872) Glomerular filtration rate in chronic kidney disease ( 26420894) Letter-number span reordering ( 31596458)	Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		9 interacting genes: BRAF BUB1 CDH1 CTNNA1 DLC1 ERBB2 MCC MLH3 SMAD2	80 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CSNK1E CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 IMP3 KAT5 KIF3C KIFC3 LRRC45 MAGEE1 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 STOML2 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792
Entrez ID		3293	4163
HPRD ID		05716	01157
Ensembl ID		ENSG00000130948	ENSG00000171444
Uniprot IDs		P37058 Q6FH62	P23508
PDB IDs			6MTU 6MTV
Enriched GO Terms of Interacting Partners?
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