MCC and SFRP4

Number of citations of the paper that reports this interaction (PubMedID 24412244)
2

Data Source:
BioGRID (two hybrid)

		MCC	SFRP4
Description		MCC regulator of WNT signaling pathway	secreted frizzled related protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Lamellipodium Cytoplasmic Ribonucleoprotein Granule	Extracellular Space Nucleus Cytoplasm Cell Surface
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein Binding Wnt-protein Binding
	Biological Process	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Positive Regulation Of Receptor Internalization Negative Regulation Of Cell Population Proliferation Response To Hormone Positive Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Regulation Of BMP Signaling Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Epidermal Cell Differentiation Phosphate Ion Homeostasis Canonical Wnt Signaling Pathway Bone Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Sodium-dependent Phosphate Transport
Pathways
Drugs			Cyclothiazide Perindopril
Diseases
GWAS		Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)	Blood protein levels ( 30072576) Dupuytren's disease ( 28886342 21732829) ghrelin levels ( 33852427) Heel bone mineral density ( 30598549 28869591)
Interacting Genes		80 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CSNK1E CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 IMP3 KAT5 KIF3C KIFC3 LRRC45 MAGEE1 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 STOML2 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792	22 interacting genes: AP2M1 AQP6 AURKA BMPR1A BUB1 CDKN2A CKMT1B CTNNA1 DLC1 ERBB2 FADS2 HSD17B11 MCC NARF NRAS PDGFRL PFKM PIK3CA PMS2 PTPN12 PTPRJ SMAD4
Entrez ID		4163	6424
HPRD ID		01157	07357
Ensembl ID		ENSG00000171444	ENSG00000106483
Uniprot IDs		P23508	Q6FHJ7
PDB IDs		6MTU 6MTV
Enriched GO Terms of Interacting Partners?
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