HOXC8 and HOXD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HOXC8	HOXD3
Description		homeobox C8	homeobox D3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Microtubule Cytoskeleton	Chromatin Nucleus Nucleoplasm Aggresome Nuclear Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cell-matrix Adhesion Notch Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Thyroid Gland Development Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Cartilage Development
Pathways			Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Estimated glomerular filtration rate ( 31015462) Male-pattern baldness ( 29146897 28196072) Mucinous ovarian carcinoma ( 26075790) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Ovarian cancer ( 20852632) Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		107 interacting genes: ADAMTSL4 ANKS1A BLZF1 BMPR1A BTG2 C11orf1 C19orf54 C1orf109 CADPS CCM2 CEP70 CRYBA1 CYSRT1 DLX2 DLX5 DVL3 DZIP3 ECM1 FNTB GMNN GOLGA6L9 GSTO2 GYS1 HESX1 HOMEZ HOXD3 HSF2BP IKZF3 JUN KCTD9 KHDC1 KPRP KRT34 KRT35 KRT36 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP13-3 KRTAP19-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LDLRAP1 LDOC1 LHX2 LHX3 LRP2BP MAPK8IP2 MEOX1 MEOX2 METTL15 MGAT5B MSX1 NADSYN1 NBPF19 NFKBID NID2 NOTCH2NLA OIP5 PAX5 PAX6 PAX8 PBX1 PBX2 PBX4 PDE4DIP PFDN5 PLA2G10 PLEKHG4 POU2AF1 POU6F2 PPARA PRDM14 PRDM6 RBCK1 RBPMS SLAIN1 SMAD1 SMAD4 SMAD6 SNX17 TBC1D1 TBX19 TBX22 TEKT4 TLE5 TNS2 TRAF1 TRIB3 TRIM27 TRIM42 TRIP6 TSC1 USP54 VENTX WWOX ZFP90 ZMAT5 ZNF34 ZRANB1	7 interacting genes: ALX4 DDB1 HMGB1 HOXC8 IGFN1 NFKBID SMARCD1
Entrez ID		3224	3232
HPRD ID		00856	00863
Ensembl ID		ENSG00000037965	ENSG00000128652
Uniprot IDs		P31273	P31249
PDB IDs
Enriched GO Terms of Interacting Partners?
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