HMGA1 and ANXA2

Number of citations of the paper that reports this interaction (PubMedID 18850631)
12

Data Source:
BioGRID (far western blotting)

		HMGA1	ANXA2
Description		high mobility group AT-hook 1	annexin A2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Focal Adhesion Senescence-associated Heterochromatin Focus RNA Polymerase II Transcription Regulator Complex	Ruffle Extracellular Region Basement Membrane Extracellular Space Nucleus Cytoplasm Lysosomal Membrane Endosome Early Endosome Lipid Droplet Cytosol Plasma Membrane Adherens Junction Cell Cortex Cell Surface Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Midbody Late Endosome Membrane Vesicle Azurophil Granule Lumen Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Macropinosome Membrane Raft Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome AnxA2-p11 Complex PCSK9-AnxA2 Complex
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Enzyme Binding Nuclear Receptor Coactivator Activity Structural Constituent Of Chromatin Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Retinoid X Receptor Binding	Phosphatidylserine Binding Protease Binding RNA Binding Serine-type Endopeptidase Inhibitor Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Phospholipase A2 Inhibitor Activity Small GTPase Binding Identical Protein Binding S100 Protein Binding Bone Sialoprotein Binding Virion Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	DNA Unwinding Involved In DNA Replication Nucleosome Disassembly Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Oncogene-induced Cell Senescence Positive Regulation Of Cellular Senescence	Angiogenesis Membrane Raft Assembly Positive Regulation Of Receptor Recycling Positive Regulation Of Protein Phosphorylation Vesicle Budding From Membrane Body Fluid Secretion Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Positive Regulation Of Vesicle Fusion Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Osteoclast Development Fibrinolysis Positive Regulation Of Vacuole Organization Positive Regulation Of Fibroblast Proliferation Calcium Ion Transmembrane Transport Protein Localization To Plasma Membrane Response To Thyroid Hormone Cell-cell Adhesion Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Low-density Lipoprotein Receptor Activity Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways		Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Smooth Muscle Contraction Neutrophil degranulation Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Tenecteplase Fluocinolone acetonide Lanoteplase Artenimol
Diseases
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758 27680694) Body mass index ( 26426971 28892062 20935630) Body shape index ( 34021172) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 21998595 34054925 20881960 25282103 25429064 19396169 19343178 19893584 23563607 31562340 18391951 20397748 20189936) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172 25673412) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Myeloproliferative neoplasms ( 33057200) Offspring birth weight ( 31043758) Plateletcrit ( 32888494) Regular attendance at a gym or sports club ( 29970889) Systolic blood pressure ( 30578418) Tonsillectomy ( 27182965 28928442) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Type 2 diabetes (adjusted for BMI) ( 30297969) Uterine fibroids ( 31649266) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 25673412) Weight ( 34054925)	Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576 28240269) Night sleep phenotypes ( 27126917) Type 2 diabetes ( 25102180)
Interacting Genes		64 interacting genes: ANXA1 ANXA2 APEX1 APP ATF2 CDK1 CEBPB CREBBP CSNK2A1 CSNK2A2 CWC27 DNAJC8 EIF2S2 ELF1 EWSR1 GTF2F2 HEMGN HIPK2 HMGB1 HMGB2 HMGB3 HNRNPA1 HNRNPAB HNRNPD HNRNPDL HNRNPL HPF1 HSPA1A IRF1 JUN KAT2B METAP2 NCL NFKB1 NFYA NPM1 OLA1 ORC6 PA2G4 PARP1 PCBP1 PCBP2 POU2F1 POU2F2 POU3F1 PPARG PPP1R8 PRKCA PRMT6 PSIP1 PTBP1 RARA RARG RCC1 RN7SK RNF4 RXRA SP1 SRF SRPK2 SSB SUFU SYNCRIP UPF2	46 interacting genes: ACTA1 APOH APP CCDC32 CD99 CDC42 CEACAM1 CTSB CTSS DYSF GRB2 HMGA1 LGALS13 LINC01554 LYPLA1 MAP3K4 MYOC NOD2 OGDH PHB PLA1A PLA2G4A PLAT PLG POT1 PRKCA PRKCB PTEN RPS2 S100A10 S100A4 S100A6 SLC26A4-AS1 SMAD6 SMN1 SNX17 SOS1 SRC STAT6 TENT2 TERF1 TERT TNC TRPV5 YWHAQ ZBTB4
Entrez ID		3159	302
HPRD ID		02829	01061
Ensembl ID		ENSG00000137309	ENSG00000182718
Uniprot IDs		P17096 Q5T6U8	A0A024R5Z7 H0YL33 P07355
PDB IDs		2EZD 2EZE 2EZF 2EZG	1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4FTG 4HRH 5LPU 5LPX 5LQ0 5LQ2 5N7D 5N7F 5N7G 6TWQ 6TWU 6TWX 6TWY
Enriched GO Terms of Interacting Partners?
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