HMGCL and RNF126

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		HMGCL	RNF126
Description		3-hydroxy-3-methylglutaryl-CoA lyase	ring finger protein 126
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Fatty-acyl-CoA Binding Magnesium Ion Binding Hydroxymethylglutaryl-CoA Lyase Activity Structural Molecule Activity Manganese Ion Binding Carboxylic Acid Binding Metal Ion Binding	Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Liver Development Leucine Catabolic Process Lipid Metabolic Process Acyl-CoA Metabolic Process Mitochondrion Organization Response To Nutrient Response To Starvation Ketone Body Biosynthetic Process Response To Fatty Acid	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System
Pathways		Synthesis of Ketone Bodies Peroxisomal protein import Peroxisomal protein import	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		3-hydroxyglutaric acid
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 27863252)	Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Pulse pressure ( 30578418)
Interacting Genes		10 interacting genes: ADAMTS10 ARL6IP1 DNAJA1 GTF2B HES1 HSD17B10 MS4A7 PEX5 RNF126 SMARCA4	40 interacting genes: ABCG2 AICDA BAG6 CENPP CSNK2B E2F1 EGFR FXN G0S2 HMGCL MAP3K1 MDM2 MIEN1 NUDT3 OTUB1 OTUB2 PLK1 PSMF1 RBX1 RNF168 SNUPN TRIM11 TRIM23 TRIM26 TRIM52 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBL3 UBL4A USP15 USP2 XRCC5 XRCC6
Entrez ID		3155	55658
HPRD ID		02003	11501
Ensembl ID		ENSG00000117305	ENSG00000070423
Uniprot IDs		P35914	A0A024R206 A8K0Q1 Q9BV68
PDB IDs		2CW6 3MP3 3MP4 3MP5	2N9O 2N9P
Enriched GO Terms of Interacting Partners?
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