HMGCL and ARL6IP1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		HMGCL	ARL6IP1
Description		3-hydroxy-3-methylglutaryl-CoA lyase	ADP ribosylation factor like GTPase 6 interacting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Protein-containing Complex	Sec61 Translocon Complex Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Fatty-acyl-CoA Binding Magnesium Ion Binding Hydroxymethylglutaryl-CoA Lyase Activity Structural Molecule Activity Manganese Ion Binding Carboxylic Acid Binding Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Liver Development Leucine Catabolic Process Lipid Metabolic Process Acyl-CoA Metabolic Process Mitochondrion Organization Response To Nutrient Response To Starvation Ketone Body Biosynthetic Process Response To Fatty Acid	Positive Regulation Of L-glutamate Import Across Plasma Membrane Cotranslational Protein Targeting To Membrane Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Endoplasmic Reticulum Tubular Network Formation Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Membrane Organization
Pathways		Synthesis of Ketone Bodies Peroxisomal protein import Peroxisomal protein import
Drugs		3-hydroxyglutaric acid
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 27863252)	Caffeine consumption from coffee or tea ( 33287642) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: ADAMTS10 ARL6IP1 DNAJA1 GTF2B HES1 HSD17B10 MS4A7 PEX5 RNF126 SMARCA4	77 interacting genes: ACSF2 AQP6 ARL4D ARL6 C19orf18 CERT1 DIABLO EHD3 EMP1 F2RL1 FBXW7 FDFT1 FXR2 GAD2 GAS8 GOLPH3 GOLPH3L GORASP2 GPR151 GPR152 HGS HMGCL HSD17B13 INPP5K LMNA MCEMP1 MFSD14B MFSD5 MGST3 MIEF2 MTERF3 MYG1 NAPB NDRG4 NTAQ1 NUDT3 PAM16 PBX3 PICK1 PTPN9 RAB33A REEP6 RETREG3 RNF5 SDCBP SENP2 SHISA5 SHMT2 SLC10A6 SLC13A1 SLC35C2 SNX1 SNX10 SNX11 SNX12 SNX15 SNX2 SNX3 SNX4 SNX8 SPG21 STARD4 SUCLA2 TARS2 TFAM TMED8 TMEM14B TMEM248 TMEM258 TUFM UBE2I VMA21 WDFY2 WIPI2 YIPF4 ZFYVE21 ZNF391
Entrez ID		3155	23204
HPRD ID		02003	09641
Ensembl ID		ENSG00000117305	ENSG00000170540
Uniprot IDs		P35914	A0A024QYV7 Q15041
PDB IDs		2CW6 3MP3 3MP4 3MP5
Enriched GO Terms of Interacting Partners?
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