HDAC1 and STAT3

Number of citations of the paper that reports this interaction (PubMedID 15653507)
315

Data Source:
BioGRID (affinity chromatography technology, imaging technique)
HPRD (in vivo)

		HDAC1	STAT3
Description		histone deacetylase 1	signal transducer and activator of transcription 3
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm Cytosol Sin3 Complex NuRD Complex Transcription Repressor Complex Protein-containing Complex Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane Postsynaptic Density RNA Polymerase II Transcription Regulator Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding P53 Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Deacetylase Activity Enzyme Binding Nucleosomal DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Krueppel-associated Box Domain Binding Histone Deacetylase Binding Protein N-terminus Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Signaling Receptor Binding Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Phosphatase Binding Chromatin DNA Binding CCR5 Chemokine Receptor Binding Glucocorticoid Receptor Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Primary MiRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Amphetamine Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Heterochromatin Assembly Regulation Of Transcription By RNA Polymerase II Protein Deacetylation Endoderm Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Epidermal Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Myotube Differentiation Histone Deacetylation Hippocampus Development Neuron Differentiation Response To Caffeine Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Neuron Apoptotic Process Negative Regulation By Host Of Viral Transcription Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Endopeptidase Activity Response To Hyperoxia Negative Regulation Of Androgen Receptor Signaling Pathway Hair Follicle Placode Formation Eyelid Development In Camera-type Eye Fungiform Papilla Formation Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Tumor Necrosis Factor Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Amyloid-beta Clearance Positive Regulation Of Signaling Receptor Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Temperature Homeostasis Eye Photoreceptor Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Defense Response Acute-phase Response Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Receptor Signaling Pathway Via JAK-STAT Nervous System Development Aging Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Phosphorylation Cytokine-mediated Signaling Pathway Stem Cell Population Maintenance Sexual Reproduction Positive Regulation Of Cell Migration Intracellular Receptor Signaling Pathway Response To Estradiol Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Hormone Stimulus Leptin-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Glucose Homeostasis Eating Behavior MRNA Transcription By RNA Polymerase II Response To Peptide Hormone Cellular Response To Leptin Stimulus Response To Leptin Response To Ethanol Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitochondrial Membrane Permeability Astrocyte Differentiation Modulation Of Chemical Synaptic Transmission Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cell Cycle Radial Glial Cell Differentiation Regulation Of Feeding Behavior Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Cellular Response To Organic Cyclic Compound T-helper 17 Type Immune Response T-helper 17 Cell Lineage Commitment Energy Homeostasis Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Neuron Death Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of MiRNA Mediated Inhibition Of Translation Negative Regulation Of Primary MiRNA Processing Positive Regulation Of Gene Silencing By MiRNA Negative Regulation Of Stem Cell Differentiation Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Neuron Migration
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 p75NTR negatively regulates cell cycle via SC1 Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Deactivation of the beta-catenin transactivating complex ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Repression of WNT target genes Repression of WNT target genes Regulation of TP53 Activity through Acetylation G1/S-Specific Transcription RNA Polymerase I Transcription Initiation RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Potential therapeutics for SARS STAT3 nuclear events downstream of ALK signaling Factors involved in megakaryocyte development and platelet production	Interleukin-6 signaling BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signalling to STAT3 Signaling by ALK Senescence-Associated Secretory Phenotype (SASP) Signaling by Leptin POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Association of TriC/CCT with target proteins during biosynthesis Transcriptional regulation of pluripotent stem cells Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling PTK6 Activates STAT3 PTK6 Activates STAT3 Interleukin-20 family signaling MET activates STAT3 MET activates STAT3 Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-37 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-21 signaling Transcriptional regulation of granulopoiesis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF3 (G-CSF) STAT3 nuclear events downstream of ALK signaling Inactivation of CSF3 (G-CSF) signaling Cytoprotection by HMOX1 Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer Growth hormone receptor signaling
Drugs		Arsenic trioxide Zinc Vorinostat Belinostat Pracinostat Romidepsin Panobinostat Fingolimod Mocetinostat Abexinostat Zinc acetate Zinc chloride Zinc sulfate, unspecified form	ENMD-1198
Diseases
GWAS			Apolipoprotein B levels ( 32203549) Atopic dermatitis ( 26482879) Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Crohn's disease ( 18587394 28067908 21102463 23266558) Crohn's disease or systemic sclerosis ( 32024964) Diastolic blood pressure ( 30578418) Inflammatory bowel disease ( 27569725 28067908 26278503 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244 22190364 24076602 21833088 20159113) Myocardial infarction ( 33532862) Psoriasis ( 25903422 23143594) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458) Ulcerative colitis ( 28067908)
Interacting Genes		191 interacting genes: APEX1 AR ARID4A ATF3 ATRX BAZ2A BCL11A BCL3 BCL6 BCL6B BCOR BHLHE40 BRCA1 BRMS1 BRMS1L BUB1 BUB1B BUB3 CBFA2T3 CCN5 CDC20 CDH1 CDKN1A CDYL CHD1 CHD4 CHFR CIITA CREBBP CREM CSNK2A1 CSNK2A2 CTBP1 CYTOR DAXX DDB2 DDX17 DHX30 DNMT1 DNMT3A DNMT3B DNMT3L EED EID2 EID2B ELK1 ENO1 EP300 ERCC6 EZH2 FKBP3 FOXG1 FRA10F GATA3 GCM1 GPS2 H2AC1 H3-4 H3C1 HBP1 HDAC2 HDAC3 HDAC7 HDAC9 HELLS HEY2 HIC1 HIF1A HIF1AN HNRNPD HR HUS1 ICAM1 IKZF1 ING1 IRF5 JDP2 KAT5 KCTD11 KDM1A KLF1 KLF11 KLF4 KLF5 LCOR MAD1L1 MAGEA1 MBD2 MBD3 MBD3L2 MBD4 MDM2 MECOM MECP2 MEN1 MIER1 MORF4L2 MTA1 MXD1 MYOD1 NCOR2 NFE4 NFKB1 NFKBIA NKX2-5 NKX3-2 NR1D2 NR2E3 NR2F2 NR3C1 NRIP1 NUP98 OGT PARP1 PCNA PEX14 PHB PHB2 PHF12 PHF21A PIAS3 PIAS4 PITX2 PML PPARD PPARG PPP2R1B PRKACA PRKG1 PRRG4 PTMA RAD9A RAP1A RARA RB1 RBBP4 RBBP7 RBL1 RBL2 RBP1 RBPJ RELA REPIN1 RFC1 RFC4 RUNX1T1 RUNX3 RUVBL2 SALL1 SAP18 SAP30 SATB1 SATB2 SENP1 SERPINB5 SETDB1 SIN3A SIN3B SMAD2 SMAD3 SOX6 SP1 SP3 SPEN SPI1 STAT2 STAT3 SUDS3 SUMO2 SUV39H1 SYK TAB2 TAL1 TFCP2 TGIF1 TGIF2 THAP11 TNIP1 TOP2A TOP2B TP53 TPD52L1 TRIM27 TXNIP UBE2I USP38 USP43 VHL ZBTB16 ZMYND11 ZNF76	211 interacting genes: ABL2 ADRB2 AMBP AR ARFIP2 ASXL1 ATF3 BATF3 BCKDK BHLHE40 BICD1 BLK BMX BRCA1 BRWD1 CA8 CAPN1 CAPNS1 CBL CCDC87 CCND1 CCR1 CCR5 CDK9 CDKN1A CEP120 CHTF18 CNDP2 CORO1A CREBBP CSF2RB CSF3R CXCR4 DAXX DOK2 DOK3 DTNA ECH1 EGFR EIF2AK2 ELP2 EP300 EPHA3 ERBB2 ERBIN ESR1 FAM117B FBXW7 FER FES FGFR3 FGFR4 FGR FHL2 FLT1 FOXM1 FYN GAS5 GATA1 GATA2 GHR GNL3 GSTCD GTF2I HCK HDAC1 HDAC2 HDAC3 HES1 HES5 HESX1 HIF1A HIVEP1 HLA-A HNF1A HNRNPM HOXC11 HSP90AA1 HSP90AB1 IFNAR1 IFNAR2 IGF1R IL1RAP IL22RA1 IL23R IL2RA IL2RB IL6R IL6ST IL7R IMPDH2 IRAK1 JAK1 JAK2 JAK3 JUN KAT5 KDM1A KHDRBS1 KLF15 KPNA1 KPNA6 KRTAP10-7 LAMB2 LASP1 LCK LEPR LMO2 LYN MAP3K13 MAP3K7 MAPK1 MAPK3 MAPK8 MAPKAPK2 MEG3 MET MNDA MORC4 MPZL1 MRPS31 MTOR MYOD1 NACAD NCOA1 NDUFA13 NFE2L2 NFKB1 NFKBIZ NIF3L1 NLK NMI NR3C1 NR4A1 NUFIP2 NXT2 OFCC1 OGDHL PAFAH1B2 PAQR7 PCBD2 PDGFRA PDGFRB PDIA3 PELP1 PIAS3 PIK3R1 PIK3R2 PIK3R3 PINK1 PML POM121 PPARD PRKCD PTK2B PTMA PTPN1 PTPN11 PTPN2 RABGAP1 RAC1 RACK1 RB1 RELA RET RPA2 RPL11 RPS6KA5 RPS9 RRAD SCAF11 SETD7 SH2D2A SH3BP2 SIAH2 SIN3A SMARCA4 SPRY1 SRC SRI SRRT SS18L1 STAP2 STAT1 STAT4 STAT5A STAT5B STAT6 STMN1 SULT2A1 SUMO4 SUPT20H SYK TAB3 TASOR2 TDG TM4SF19 TRIM28 TRIP10 TSHR TSLP TWIST1 VPS39 WDFY3 ZFPM2 ZNF148 ZNF281 ZNF467 ZNF557 ZNF829 ZNRD2
Entrez ID		3065	6774
HPRD ID		03143	00026
Ensembl ID		ENSG00000116478	ENSG00000168610
Uniprot IDs		Q13547 Q6IT96	A0A7I2V395 P40763
PDB IDs		1TYI 4BKX 5ICN 6Z2J 6Z2K 7AO8 7AO9 7AOA	5AX3 5U5S 6NJS 6NUQ 6QHD 6TLC
Enriched GO Terms of Interacting Partners?
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