STAT3 and EPHA3

Number of citations of the paper that reports this interaction (PubMedID 16186805)
46

Data Source:
HPRD (in vitro)

		STAT3	EPHA3
Description		signal transducer and activator of transcription 3	EPH receptor A3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane Postsynaptic Density RNA Polymerase II Transcription Regulator Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Extracellular Region Nucleoplasm Early Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton Nuclear Membrane Neuron Projection Receptor Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Signaling Receptor Binding Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Phosphatase Binding Chromatin DNA Binding CCR5 Chemokine Receptor Binding Glucocorticoid Receptor Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Primary MiRNA Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Temperature Homeostasis Eye Photoreceptor Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Defense Response Acute-phase Response Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Receptor Signaling Pathway Via JAK-STAT Nervous System Development Aging Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Phosphorylation Cytokine-mediated Signaling Pathway Stem Cell Population Maintenance Sexual Reproduction Positive Regulation Of Cell Migration Intracellular Receptor Signaling Pathway Response To Estradiol Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Hormone Stimulus Leptin-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Glucose Homeostasis Eating Behavior MRNA Transcription By RNA Polymerase II Response To Peptide Hormone Cellular Response To Leptin Stimulus Response To Leptin Response To Ethanol Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitochondrial Membrane Permeability Astrocyte Differentiation Modulation Of Chemical Synaptic Transmission Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cell Cycle Radial Glial Cell Differentiation Regulation Of Feeding Behavior Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Cellular Response To Organic Cyclic Compound T-helper 17 Type Immune Response T-helper 17 Cell Lineage Commitment Energy Homeostasis Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Neuron Death Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of MiRNA Mediated Inhibition Of Translation Negative Regulation Of Primary MiRNA Processing Positive Regulation Of Gene Silencing By MiRNA Negative Regulation Of Stem Cell Differentiation Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Neuron Migration	Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Kinase Activity Regulation Of GTPase Activity Negative Regulation Of Endocytosis Ephrin Receptor Signaling Pathway Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Retinoic Acid Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Interleukin-6 signaling BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signalling to STAT3 Signaling by ALK Senescence-Associated Secretory Phenotype (SASP) Signaling by Leptin POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Association of TriC/CCT with target proteins during biosynthesis Transcriptional regulation of pluripotent stem cells Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling PTK6 Activates STAT3 PTK6 Activates STAT3 Interleukin-20 family signaling MET activates STAT3 MET activates STAT3 Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-37 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-21 signaling Transcriptional regulation of granulopoiesis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF3 (G-CSF) STAT3 nuclear events downstream of ALK signaling Inactivation of CSF3 (G-CSF) signaling Cytoprotection by HMOX1 Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer Growth hormone receptor signaling	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		ENMD-1198	Fostamatinib
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Atopic dermatitis ( 26482879) Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Crohn's disease ( 18587394 28067908 21102463 23266558) Crohn's disease or systemic sclerosis ( 32024964) Diastolic blood pressure ( 30578418) Inflammatory bowel disease ( 27569725 28067908 26278503 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244 22190364 24076602 21833088 20159113) Myocardial infarction ( 33532862) Psoriasis ( 25903422 23143594) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458) Ulcerative colitis ( 28067908)	Adult body size ( 32376654) Atrial fibrillation ( 30061737 29892015) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Lateral thalamic nuclei volume ( 34006833) Loneliness (multivariate analysis) ( 27629369) Lung function (FVC) ( 26635082) Orofacial clefts ( 22863734) Periodontitis (Mean PAL) ( 24024966) Post-bronchodilator FEV1 x air pollution (NO2) interaction in childhood asthma ( 31028280) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 27841878) Tea consumption ( 31046077) Thrombosis ( 26908601) Ventral thalamic nuclei volume ( 34006833) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Weight ( 34074324)
Interacting Genes		211 interacting genes: ABL2 ADRB2 AMBP AR ARFIP2 ASXL1 ATF3 BATF3 BCKDK BHLHE40 BICD1 BLK BMX BRCA1 BRWD1 CA8 CAPN1 CAPNS1 CBL CCDC87 CCND1 CCR1 CCR5 CDK9 CDKN1A CEP120 CHTF18 CNDP2 CORO1A CREBBP CSF2RB CSF3R CXCR4 DAXX DOK2 DOK3 DTNA ECH1 EGFR EIF2AK2 ELP2 EP300 EPHA3 ERBB2 ERBIN ESR1 FAM117B FBXW7 FER FES FGFR3 FGFR4 FGR FHL2 FLT1 FOXM1 FYN GAS5 GATA1 GATA2 GHR GNL3 GSTCD GTF2I HCK HDAC1 HDAC2 HDAC3 HES1 HES5 HESX1 HIF1A HIVEP1 HLA-A HNF1A HNRNPM HOXC11 HSP90AA1 HSP90AB1 IFNAR1 IFNAR2 IGF1R IL1RAP IL22RA1 IL23R IL2RA IL2RB IL6R IL6ST IL7R IMPDH2 IRAK1 JAK1 JAK2 JAK3 JUN KAT5 KDM1A KHDRBS1 KLF15 KPNA1 KPNA6 KRTAP10-7 LAMB2 LASP1 LCK LEPR LMO2 LYN MAP3K13 MAP3K7 MAPK1 MAPK3 MAPK8 MAPKAPK2 MEG3 MET MNDA MORC4 MPZL1 MRPS31 MTOR MYOD1 NACAD NCOA1 NDUFA13 NFE2L2 NFKB1 NFKBIZ NIF3L1 NLK NMI NR3C1 NR4A1 NUFIP2 NXT2 OFCC1 OGDHL PAFAH1B2 PAQR7 PCBD2 PDGFRA PDGFRB PDIA3 PELP1 PIAS3 PIK3R1 PIK3R2 PIK3R3 PINK1 PML POM121 PPARD PRKCD PTK2B PTMA PTPN1 PTPN11 PTPN2 RABGAP1 RAC1 RACK1 RB1 RELA RET RPA2 RPL11 RPS6KA5 RPS9 RRAD SCAF11 SETD7 SH2D2A SH3BP2 SIAH2 SIN3A SMARCA4 SPRY1 SRC SRI SRRT SS18L1 STAP2 STAT1 STAT4 STAT5A STAT5B STAT6 STMN1 SULT2A1 SUMO4 SUPT20H SYK TAB3 TASOR2 TDG TM4SF19 TRIM28 TRIP10 TSHR TSLP TWIST1 VPS39 WDFY3 ZFPM2 ZNF148 ZNF281 ZNF467 ZNF557 ZNF829 ZNRD2	29 interacting genes: ABL1 ADAM10 CDKN2A CRK CTDSP2 DUSP18 DUSP21 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 ERBB2 FBXO7 FYN ILKAP MTMR11 PIM1 RBM18 RUFY1 RUFY2 SRC SRPK1 STAT3 STYX TP53 TPTE
Entrez ID		6774	2042
HPRD ID		00026	01555
Ensembl ID		ENSG00000168610	ENSG00000044524
Uniprot IDs		A0A7I2V395 P40763	A0A140VJJ0 C9JXA2 P29320 Q6P4R6
PDB IDs		5AX3 5U5S 6NJS 6NUQ 6QHD 6TLC	2GSF 2QO2 2QO7 2QO9 2QOB 2QOC 2QOD 2QOF 2QOI 2QOK 2QOL 2QON 2QOO 2QOQ 3DZQ 3FXX 3FY2 4G2F 4GK2 4GK3 4GK4 4L0P 4P4C 4P5Q 4P5Z 4TWN 4TWO 6IN0
Enriched GO Terms of Interacting Partners?
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