HCFC1 and FOXK2

Number of citations of the paper that reports this interaction (PubMedID 24748658)
30

Data Source:
BioGRID (pull down)

		HCFC1	FOXK2
Description		host cell factor C1	forkhead box K2
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytoplasm Membrane Axon Dendrite Protein-containing Complex Histone Methyltransferase Complex Neuronal Cell Body Set1C/COMPASS Complex MLL1 Complex	Chromatin Nucleus Nucleoplasm Mitochondrion Intracellular Membrane-bounded Organelle
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Cadherin Binding DNA-binding Transcription Factor Binding	Magnesium Ion Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Transcription, DNA-templated Cell Cycle Positive Regulation Of Gene Expression Release From Viral Latency Regulation Of Protein-containing Complex Assembly Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Cellular Response To Organic Cyclic Compound	Negative Regulation Of Transcription By RNA Polymerase II Cellular Glucose Homeostasis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Autophagy Regulation Of Glucose Metabolic Process Response To Starvation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Canonical Glycolysis
Pathways		Transcriptional activation of mitochondrial biogenesis HATs acetylate histones UCH proteinases	UCH proteinases
Drugs
Diseases
GWAS		Celiac disease ( 22057235) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 26502338)	Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lean body mass ( 28552196) Letter-number span reordering ( 31596458) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		34 interacting genes: ASF1B CLP1 CREB3 CREBZF E2F1 E2F3 E2F4 EGR2 FOXK2 GABPA GABPB1 HCFC1R1 HSPA1A JUN KMT2A MED25 NFE2L1 OGT PDCD2 POU2F1 PPARGC1A PPARGC1B PPP1CC PSIP1 SETD7 SIAH1 SIN3A SP1 SUMO2 TAF9 THAP11 THAP7 YY1 ZBTB17	11 interacting genes: ASXL1 ESR1 HCFC1 IL2 MTA3 RBBP4 RBBP7 RCOR1 SIN3A TBL1X TBL1XR1
Entrez ID		3054	3607
HPRD ID		02061	00982
Ensembl ID		ENSG00000172534	ENSG00000141568
Uniprot IDs		A6NEM2 P51610	Q01167
PDB IDs		4GO6 4N39 4N3A 4N3B 4N3C 5LWV 6MA1 6MA2 6MA3 6MA4 6MA5	1JXS 2C6Y
Enriched GO Terms of Interacting Partners?
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