SH3KBP1 and NELFA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SH3KBP1	NELFA
Description		SH3 domain containing kinase binding protein 1	negative elongation factor complex member A
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Endocytic Vesicle Cytoplasmic Vesicle Membrane Neuron Projection Synapse	Nucleoplasm Cytosol Nuclear Body NELF Complex
	Molecular Function	Protein Binding SH3 Domain Binding	Chromatin Binding Protein Binding
	Biological Process	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Regulation Of Cell Shape Cell Migration Positive Regulation Of B Cell Activation	Multicellular Organism Development Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Histone H3-K4 Methylation
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Platelet count ( 32888494)
Interacting Genes		60 interacting genes: ABI2 ANKS1A ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BHLHB9 BLNK BMPR1B CAPZA1 CBL CBLB CCDC57 CCDC88B CD2 CYSRT1 DENND2A EGLN1 GGN GRB2 HCK HIVEP1 INPP5D ITSN2 KPRP KRTAP6-3 LZTS2 MET MVB12A NEDD4 NELFA PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 POLR2K PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 TP53BP2 UBB UBC UBE2I ZBTB7B ZNF219	12 interacting genes: APP CDK3 MLH1 NCK2 NELFCD NSD2 OPRM1 PIN1 PRR22 SH3KBP1 SIAH1 SMARCD1
Entrez ID		30011	7469
HPRD ID		02301	12080
Ensembl ID		ENSG00000147010	ENSG00000185049
Uniprot IDs		B7Z6E8 Q5JPT6 Q96B97	A0A0C4DFX9 Q9H3P2
PDB IDs		2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS	5L3X 6GML
Enriched GO Terms of Interacting Partners?
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