SH3KBP1 and EGLN1

Number of citations of the paper that reports this interaction (PubMedID 31142511)
3

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SH3KBP1	EGLN1
Description		SH3 domain containing kinase binding protein 1	egl-9 family hypoxia inducible factor 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Endocytic Vesicle Cytoplasmic Vesicle Membrane Neuron Projection Synapse	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding SH3 Domain Binding	Protein Binding Ferrous Iron Binding 2-oxoglutarate-dependent Dioxygenase Activity Enzyme Binding L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity
	Biological Process	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Regulation Of Cell Shape Cell Migration Positive Regulation Of B Cell Activation	Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Oxygen Homeostasis Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Angiogenesis Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Cellular Response To Hypoxia Response To Nitric Oxide
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs			Ascorbic acid Iron Roxadustat N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE FG-2216 Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Platelet count ( 32888494)	Cutaneous mastocytosis ( 32752121) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High altitude adaptation ( 28373541) Metabolite levels ( 23823483) Red blood cell count ( 32888494 27863252)
Interacting Genes		60 interacting genes: ABI2 ANKS1A ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BHLHB9 BLNK BMPR1B CAPZA1 CBL CBLB CCDC57 CCDC88B CD2 CYSRT1 DENND2A EGLN1 GGN GRB2 HCK HIVEP1 INPP5D ITSN2 KPRP KRTAP6-3 LZTS2 MET MVB12A NEDD4 NELFA PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 POLR2K PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 TP53BP2 UBB UBC UBE2I ZBTB7B ZNF219	13 interacting genes: DISC1 EPAS1 HIF1A HIF3A HSP90AA1 ING4 KRAS OS9 PLD1 SH3KBP1 SRC VHL ZNF281
Entrez ID		30011	54583
HPRD ID		02301	06971
Ensembl ID		ENSG00000147010	ENSG00000135766
Uniprot IDs		B7Z6E8 Q5JPT6 Q96B97	Q9GZT9 R4SCQ0
PDB IDs		2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS	2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4JZR 4KBZ 4UWD 5A3U 5L9B 5L9R 5L9V 5LA9 5LAS 5LAT 5LB6 5LBB 5LBC 5LBE 5LBF 5OX5 5OX6 5V18 6NMQ 6QGV 6ST3 6YVT 6YVW 6YVX 6YVZ 6YW0 6YW1 6YW2 6YW3 6YW4
Enriched GO Terms of Interacting Partners?
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