PACSIN1 and TPM4

Number of citations of the paper that reports this interaction (PubMedID 20936779)
88

Data Source:
BioGRID (two hybrid)

		PACSIN1	TPM4
Description		protein kinase C and casein kinase substrate in neurons 1	tropomyosin 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane COPI-coated Vesicle Cytoplasmic Vesicle Membrane Ruffle Membrane Axon Terminus Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynaptic Endocytic Zone	Stress Fiber Podosome Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Focal Adhesion Membrane Cortical Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Identical Protein Binding	Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Projection Morphogenesis Protein Localization To Membrane Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Dendrite Development	Osteoblast Differentiation Muscle Contraction Actin Filament Organization
Pathways		Clathrin-mediated endocytosis	Striated Muscle Contraction Smooth Muscle Contraction RHOV GTPase cycle Signaling by ALK fusions and activated point mutants
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Electrocardiographic traits (multivariate) ( 32602732) Free thyroxine concentration ( 30367059) High density lipoprotein cholesterol levels ( 30498476) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 28552196)	Longevity ( 33657282) Mean platelet volume ( 31080455 22139419 32888494 22423221 27863252) Platelet count ( 26805783 22139419 32888494 22423221 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252)
Interacting Genes		25 interacting genes: ANKRD24 ARHGAP17 DNM1 EHBP1 FTH1 GAS7 HTT ITCH JADE2 KAT7 KHDRBS1 MAPT MT-ATP8 PACSIN2 PACSIN3 PLEKHF2 POT1 RTKN2 SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL	14 interacting genes: DANCR JRK LNX1 NOD2 PACSIN1 PICK1 PRKACA RAB8A SMURF1 SNAPIN TCERG1 TPM1 TPM3 TRIP6
Entrez ID		29993	7171
HPRD ID		05936	11734
Ensembl ID		ENSG00000124507	ENSG00000167460
Uniprot IDs		Q5TZC3 Q9BY11	A0A5F9UN72 K7ENT6 P67936 V9HW56
PDB IDs		3HAH 3HAI 3Q84 3QNI
Enriched GO Terms of Interacting Partners?
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