MDFIC and RPS6KA5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		MDFIC	RPS6KA5
Description		MyoD family inhibitor domain containing	ribosomal protein S6 kinase A5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Transcription Factor Binding Cyclin Binding Tat Protein Binding DNA-binding Transcription Factor Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of JNK Cascade Positive Regulation Of Viral Transcription	Negative Regulation Of Cytokine Production Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Histone Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Histone Phosphorylation Positive Regulation Of Histone Acetylation Intracellular Signal Transduction Histone H3-S10 Phosphorylation Histone H3-S28 Phosphorylation Histone H2A-S1 Phosphorylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway
Pathways			ERK/MAPK targets CREB phosphorylation NCAM signaling for neurite out-growth Recycling pathway of L1 CD209 (DC-SIGN) signaling
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Body mass index ( 26426971 28892062) Clozapine-induced cytotoxicity ( 25656473) Drug experimentation measurement ( 30718321) General risk tolerance (MTAG) ( 30643258) Hip circumference ( 28552196) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Number of sexual partners ( 30643258) Obesity ( 23818313) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Smoking status (ever vs never smokers) ( 30643258) Tonsillectomy ( 27182965 28928442)	Adult body size ( 32376654) Bitter alcoholic beverage consumption ( 31046077) Body shape index ( 34021172) Femoral neck bone mineral density ( 29499414 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 29499414) Multiple sclerosis ( 31604244) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: CCNT1 CDK9 RPS6KA5 SOCS4	60 interacting genes: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CSNK2B CTNNA3 DDAH2 DNAJC11 EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 H1-1 H1-5 H2AW H2BC21 H2BC3 H2BU1 H3-4 H3C14 H3C6 H4-16 H4C14 HMGN1 HSPB2 IL17RB ITSN1 MAP3K20 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZNF775
Entrez ID		29969	9252
HPRD ID		17103	06789
Ensembl ID		ENSG00000135272	ENSG00000100784
Uniprot IDs		Q9P1T7	O75582
PDB IDs			1VZO 3KN5 3KN6
Enriched GO Terms of Interacting Partners?
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