EPN1 and AP2A2

Number of citations of the paper that reports this interaction (PubMedID 9723620)
179

Data Source:
HPRD (in vitro)

		EPN1	AP2A2
Description		epsin 1	adaptor related protein complex 2 subunit alpha 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endosome Cytosol Plasma Membrane Clathrin-coated Pit Clathrin Vesicle Coat	Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Phospholipid Binding Clathrin Binding	Molecular_function Protein Binding Lipid Binding Protein Kinase Binding Clathrin Adaptor Activity Disordered Domain Specific Binding Cargo Adaptor Activity
	Biological Process	In Utero Embryonic Development Endocytosis Notch Signaling Pathway Female Pregnancy Embryonic Organ Development Negative Regulation Of Sprouting Angiogenesis	Intracellular Protein Transport Receptor-mediated Endocytosis Clathrin-dependent Endocytosis
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs		1,4-Dioxane 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Major depressive disorder ( 23377640)	Adult asthma ( 27611488) Alzheimer's disease ( 30636644) Alzheimer's disease (late onset) ( 24162737) Asthma ( 31959851) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581)
Interacting Genes		25 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 LITAF MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A UBC ZBTB16	22 interacting genes: AAGAB AMPH AP1S1 AP2B1 APP BIN1 DNAJC6 DNM1 EPN1 EPS15 HTT ILK KCNQ1DN LRPPRC NLGN3 NUMB SHC1 SLC2A8 SMAD1 SNAP91 UBC ZPR1
Entrez ID		29924	161
HPRD ID		06270	06256
Ensembl ID		ENSG00000063245	ENSG00000183020
Uniprot IDs		A0A024R4S1 Q9Y6I3	O94973
PDB IDs		1INZ 1KYD
Enriched GO Terms of Interacting Partners?
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