PARVB and ILK

Number of citations of the paper that reports this interaction (PubMedID 11402068)
58

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PARVB	ILK
Description		parvin beta	integrin linked kinase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium	Stress Fiber Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Sarcomere Lamellipodium Protein-containing Complex Neuronal Cell Body Costamere Terminal Bouton Dendritic Shaft
	Molecular Function	Actin Binding Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Integrin Binding Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Establishment Or Maintenance Of Cell Polarity Cell Projection Assembly Lamellipodium Assembly Actin Cytoskeleton Reorganization Substrate Adhesion-dependent Cell Spreading Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape	Cell Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Outflow Tract Morphogenesis Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Aging Positive Regulation Of Cell Population Proliferation Positive Regulation Of Signal Transduction Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Fibroblast Migration Negative Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Nerve Development Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Myelin Assembly Regulation Of Actin Cytoskeleton Organization Tumor Necrosis Factor-mediated Signaling Pathway Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphorylation Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Smooth Muscle Cell Proliferation Neuron Projection Morphogenesis Positive Regulation Of Dendrite Morphogenesis Regulation Of Cell Cycle Positive Regulation Of Protein Kinase B Signaling Platelet Aggregation Positive Regulation Of Canonical Wnt Signaling Pathway Supramolecular Fiber Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Hematological and biochemical traits ( 20139978) Lewy body disease ( 25188341) Monocyte count ( 32888494) Nonalcoholic fatty liver disease ( 22719876) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Response to chemotherapy in breast cancer (hypertension) (bevacizumab) ( 25117820) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Systemic sclerosis (anti-centromere-positive) ( 29293537)	Malaria ( 31844061)
Interacting Genes		2 interacting genes: ARHGEF6 ILK	44 interacting genes: AKT1 AP2A2 CASP8 CASP9 CAV1 CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 OGT PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RICTOR RNF19A RPL13 SERPINA4 SHC1 SNRNP35 SUMO2 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746
Entrez ID		29780	3611
HPRD ID		16284	03842
Ensembl ID		ENSG00000188677	ENSG00000166333
Uniprot IDs		A0A087WZB5 Q9HBI1	Q13418 V9HWF0
PDB IDs		4EDL 4EDM 4EDN	2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB
Enriched GO Terms of Interacting Partners?
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