ILK and RICTOR

Number of citations of the paper that reports this interaction (PubMedID 18339839)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		ILK	RICTOR
Description		integrin linked kinase	RPTOR independent companion of MTOR complex 2
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GO Annotations	Cellular Component	Stress Fiber Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Sarcomere Lamellipodium Protein-containing Complex Neuronal Cell Body Costamere Terminal Bouton Dendritic Shaft	Cytosol TORC2 Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Integrin Binding Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding Protein Serine Kinase Activity	Protein Binding Protein Kinase Binding Ribosome Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Cell Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Outflow Tract Morphogenesis Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Aging Positive Regulation Of Cell Population Proliferation Positive Regulation Of Signal Transduction Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Fibroblast Migration Negative Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Nerve Development Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Myelin Assembly Regulation Of Actin Cytoskeleton Organization Tumor Necrosis Factor-mediated Signaling Pathway Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphorylation Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Smooth Muscle Cell Proliferation Neuron Projection Morphogenesis Positive Regulation Of Dendrite Morphogenesis Regulation Of Cell Cycle Positive Regulation Of Protein Kinase B Signaling Platelet Aggregation Positive Regulation Of Canonical Wnt Signaling Pathway Supramolecular Fiber Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Neural Precursor Cell Proliferation	Positive Regulation Of Endothelial Cell Proliferation Embryo Development Ending In Birth Or Egg Hatching Regulation Of Gene Expression Peptidyl-serine Phosphorylation Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Positive Regulation Of TOR Signaling Regulation Of Actin Cytoskeleton Organization Regulation Of Peptidyl-serine Phosphorylation TORC2 Signaling Regulation Of GTPase Activity Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Establishment Of Cell Polarity
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions	PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Malaria ( 31844061)	Daytime sleep phenotypes ( 27126917) Immature fraction of reticulocytes ( 32888494) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Red blood cell count ( 32888494)
Interacting Genes		44 interacting genes: AKT1 AP2A2 CASP8 CASP9 CAV1 CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 OGT PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RICTOR RNF19A RPL13 SERPINA4 SHC1 SNRNP35 SUMO2 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746	20 interacting genes: ANXA10 C5orf51 CHUK CTSW CUL1 EIF4EBP1 GSK3A GSK3B IFT20 IKBKB ILK MROH2B MTOR PHKB PLCXD3 PLK1 SGK1 SIAH1 SIRT1 USP9X
Entrez ID		3611	253260
HPRD ID		03842	10682
Ensembl ID		ENSG00000166333	ENSG00000164327
Uniprot IDs		Q13418 V9HWF0	Q6R327
PDB IDs		2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB	5ZCS 6ZWM 6ZWO
Enriched GO Terms of Interacting Partners?
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