GTF2E2 and GTF2B

Number of citations of the paper that reports this interaction (PubMedID 11113176)
9

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro)

		GTF2E2	GTF2B
Description		general transcription factor IIE subunit 2	general transcription factor IIB
Image
GO Annotations	Cellular Component	Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIE Complex Cytosol Nuclear Speck	Nucleus Nucleoplasm Transcription Factor TFIID Complex Chromosome Nuclear Body Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex Transcription Preinitiation Complex
	Molecular Function	DNA Binding RNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Complex Binding Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding RNA Polymerase II General Transcription Initiation Factor Activity Acetyltransferase Activity TBP-class Protein Binding Thyroid Hormone Receptor Binding Promoter-specific Chromatin Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter	Transcriptional Start Site Selection At RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Acetylation Histone Acetylation Viral Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Core Promoter Binding RNA Polymerase II Core Complex Assembly
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases
GWAS		Cognitive performance ( 20125193) Glaucoma (primary open-angle) ( 33627673) Mean corpuscular volume ( 32888494) Metabolite levels (X-11787) ( 23934736)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Hematocrit ( 32888494) Intraocular pressure ( 29617998) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) Rosacea symptom severity ( 29771307) Systolic blood pressure ( 28135244 30578418)
Interacting Genes		26 interacting genes: APP ATF7IP CCNH CDK7 ERCC3 ERCC6 EXOC8 FOS GTF2A1 GTF2B GTF2E1 GTF2F1 GTF2F2 GTF2H1 JUN KAT5 KLF5 MCC MDM2 MNAT1 NUP62 PICK1 SND1 SUPT16H TBP XPA	57 interacting genes: ADRB2 ATF4 BCL3 CIITA CREBBP CTBP1 DEPDC7 DHX9 DRAP1 EP300 ESR1 ESRRA FBXO25 FOXF2 GOLGA6L9 GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H4 HMGCL HNF4A HSF1 IKZF1 JAK3 JUN KLF5 MCM2 MECP2 NCOA1 NCOA3 NCOA4 NCOR1 NOLC1 NR1D2 NR2F1 NR5A1 POLR2A POLR2E POU3F2 PSMC2 PSMC5 REL RELA REST SLC22A2 SRA1 TAF11 TAF9 TBP TBPL1 TCEA2 THRA TNIP1 TRAM2 VDR YWHAE
Entrez ID		2961	2959
HPRD ID		01800	08928
Ensembl ID		ENSG00000197265	ENSG00000137947
Uniprot IDs		P29084	Q00403
PDB IDs		1D8J 1D8K 5GPY 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L	1C9B 1DL6 1RLY 1RO4 1TFB 1VOL 2PHG 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5WH1 6O9L
Enriched GO Terms of Interacting Partners?
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