PDIA3 and CANX

Number of citations of the paper that reports this interaction (PubMedID 10436013)
75

Data Source:
HPRD (in vitro)

		PDIA3	CANX
Description		protein disulfide isomerase family A member 3	calnexin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Focal Adhesion Cell Surface Melanosome MHC Class I Peptide Loading Complex Phagocytic Vesicle Recycling Endosome Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Ribosome Membrane Axon Dendrite Cytoplasm Protein-containing Complex Melanosome Neuronal Cell Body Dendritic Spine Mitochondria-associated Endoplasmic Reticulum Membrane Endoplasmic Reticulum Quality Control Compartment Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Active Zone Membrane
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Identical Protein Binding	RNA Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Apolipoprotein Binding Ionotropic Glutamate Receptor Binding Unfolded Protein Binding
	Biological Process	Protein Folding Proteolysis Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cellular Response To Interleukin-7 Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Folding Aging Protein Secretion Viral Protein Processing Ubiquitin-dependent ERAD Pathway Protein Folding In Endoplasmic Reticulum Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis
Pathways		ER-Phagosome pathway ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Maturation of spike protein Maturation of spike protein Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Antihemophilic factor, human recombinant Tenecteplase Lanoteplase Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate
Diseases
GWAS		Blood protein levels ( 30072576) Lead levels ( 26025379) Liver volume ( 34128465) Triglyceride levels ( 32203549)	Daytime sleep phenotypes ( 27126917) Lymphocyte counts ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Resting heart rate ( 24680774) White blood cell count ( 32888494 27863252)
Interacting Genes		25 interacting genes: APP BACE1 CACNB2 CALR CANX ERO1A ERP27 ESR1 FBLN5 GYPC HLA-A IFNG LINC01554 MDM2 MTNR1B OGT PCAT1 PLCB2 SEC11A SLC12A3 SLC2A1 STAT3 SUMO4 TAP1 UBE3A	48 interacting genes: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F2RL1 F8 FAM107A FSHR GPR35 GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LINC01554 LPA LRP1 LTB4R2 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 NUTF2 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 SUMO1 TF TG TRA TSHR
Entrez ID		2923	821
HPRD ID		03625	00252
Ensembl ID		ENSG00000167004	ENSG00000127022
Uniprot IDs		P30101 V9HVY3	P27824
PDB IDs		2ALB 2DMM 2H8L 3F8U 6ENY
Enriched GO Terms of Interacting Partners?
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