SETD2 and H3-4

Number of citations of the paper that reports this interaction (PubMedID 24412544)
15

Data Source:
BioGRID (enzymatic study)

		SETD2	H3-4
Description		SET domain containing 2, histone lysine methyltransferase	H3.4 histone
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome	Chromosome, Telomeric Region Nucleosome Nucleus Nucleoplasm Extracellular Exosome
	Molecular Function	Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Alpha-tubulin Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Angiogenesis Morphogenesis Of A Branching Structure Neural Tube Closure Mismatch Repair Regulation Of Transcription, DNA-templated Transcription Elongation From RNA Polymerase II Promoter Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of MRNA Export From Nucleus Peptidyl-lysine Trimethylation Peptidyl-lysine Monomethylation Forebrain Development Regulation Of Cytokinesis Positive Regulation Of Interferon-alpha Production Response To Type I Interferon Nucleosome Organization Cell Migration Involved In Vasculogenesis Endodermal Cell Differentiation Mesoderm Morphogenesis Embryonic Cranial Skeleton Morphogenesis Stem Cell Differentiation Stem Cell Development Defense Response To Virus Pericardium Development Embryonic Placenta Morphogenesis Coronary Vasculature Morphogenesis Histone H3-K36 Trimethylation Histone H3-K36 Dimethylation Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Protein Localization To Chromatin	Nucleosome Assembly
Pathways		PKMTs methylate histone lysines	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Condensation of Prophase Chromosomes DNA Damage/Telomere Stress Induced Senescence Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Meiotic recombination Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Adult body size ( 32376654) Basophil count ( 32888494) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 28334899) Huntington's disease progression ( 28642124) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 32888494 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		16 interacting genes: ARX ATXN1 CIC EXOSC7 GMPPB H3-4 H3C1 HTT KLHL18 NDUFAF3 SHANK3 SIAH2 SMAD3 SPOP TEX264 TMA7	198 interacting genes: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BIRC5 BMI1 BPTF BRD7 C17orf49 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK COPRS CREBBP CTBP1 CTBP2 DCAF1 DEK DIDO1 DNMT1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EMSY EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPK HNRNPL HNRNPR HPF1 ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM1B KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2A KMT2C KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 MYB NAP1L4 NASP NBN NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 NSD2 ORC2 ORC3 ORC4 ORC5 PARP1 PARP2 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PHRF1 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRMT5 PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RIPPLY1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SGF29 SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TCF19 TDRD3 TNPO1 TRPM7 UHRF1 WDR5 ZMYM4 ZMYND11 ZNF217 ZNF516
Entrez ID		29072	8290
HPRD ID		11043	04156
Ensembl ID		ENSG00000181555	ENSG00000168148
Uniprot IDs		Q9BYW2	Q16695
PDB IDs		2A7O 2MDC 2MDI 2MDJ 4FMU 4H12 5JJY 5JLB 5JLE 5LSS 5LSX 5LSY 5LSZ 5LT6 5LT7 5LT8 5V21 5V22 6J9J 6VDB	2V1D 2YBP 2YBS 3A6N 3T6R 4V2V 4V2W 6OIE 6WAT 6WAU
Enriched GO Terms of Interacting Partners?
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