SETD2 and TEX264

		SETD2	TEX264
Description		SET domain containing 2, histone lysine methyltransferase	testis expressed 264, ER-phagy receptor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome	Autophagosome Membrane Extracellular Region Nucleus Replication Fork Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane Platelet Alpha Granule Lumen
	Molecular Function	Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Alpha-tubulin Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)	Protein Binding Signaling Receptor Activity
	Biological Process	Angiogenesis Morphogenesis Of A Branching Structure Neural Tube Closure Mismatch Repair Regulation Of Transcription, DNA-templated Transcription Elongation From RNA Polymerase II Promoter Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of MRNA Export From Nucleus Peptidyl-lysine Trimethylation Peptidyl-lysine Monomethylation Forebrain Development Regulation Of Cytokinesis Positive Regulation Of Interferon-alpha Production Response To Type I Interferon Nucleosome Organization Cell Migration Involved In Vasculogenesis Endodermal Cell Differentiation Mesoderm Morphogenesis Embryonic Cranial Skeleton Morphogenesis Stem Cell Differentiation Stem Cell Development Defense Response To Virus Pericardium Development Embryonic Placenta Morphogenesis Coronary Vasculature Morphogenesis Histone H3-K36 Trimethylation Histone H3-K36 Dimethylation Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Protein Localization To Chromatin	Reticulophagy Protein-DNA Covalent Cross-linking Repair
Pathways		PKMTs methylate histone lysines	Platelet degranulation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Basophil count ( 32888494) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 28334899) Huntington's disease progression ( 28642124) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 32888494 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		16 interacting genes: ARX ATXN1 CIC EXOSC7 GMPPB H3-4 H3C1 HTT KLHL18 NDUFAF3 SHANK3 SIAH2 SMAD3 SPOP TEX264 TMA7	29 interacting genes: ADGRG3 ARL13B CERS4 CLDN2 CLN6 COQ9 CREB3L1 EMP1 FAM209A FFAR2 FFAR3 GABARAPL2 GJB1 GPR152 GPR42 LHFPL4 LHFPL5 MFF MS4A3 NKX3-1 OPRM1 SETD2 SLC10A2 SLC34A2 SMIM3 TM4SF18 TMEM31 TMEM79 TSPAN12
Entrez ID		29072	51368
HPRD ID		11043	15492
Ensembl ID		ENSG00000181555	ENSG00000164081
Uniprot IDs		Q9BYW2	A0A087WTU3 Q9Y6I9
PDB IDs		2A7O 2MDC 2MDI 2MDJ 4FMU 4H12 5JJY 5JLB 5JLE 5LSS 5LSX 5LSY 5LSZ 5LT6 5LT7 5LT8 5V21 5V22 6J9J 6VDB
Enriched GO Terms of Interacting Partners?
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