GPX1 and ACKR2

		GPX1	ACKR2
Description		glutathione peroxidase 1	atypical chemokine receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Lewy Body	Nucleoplasm Early Endosome Cytosol Actin Filament Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity SH3 Domain Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Triglyceride Metabolic Process Glutathione Metabolic Process Sensory Perception Of Sound Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Symbiotic Bacterium UV Protection Response To Selenium Ion Response To Gamma Radiation Protein Oxidation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Hydroperoxide Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Regulation Of Gene Expression, Epigenetic Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Regeneration Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Cell Redox Homeostasis Skeletal Muscle Fiber Development Neuron Apoptotic Process Myoblast Proliferation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Protein Kinase B Signaling Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Oxidant Detoxification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization	Endocytosis Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Multicellular Organism Development Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species	Chemokine receptors bind chemokines
Drugs		Glutathione Glutathione Glutathione disulfide Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)	Blood protein levels ( 29875488 28240269) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eotaxin levels ( 27989323) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte chemoattractant protein-1 levels ( 27989323) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Thymus and reactivation regulated chemokine levels ( 33227023) White blood cell count ( 32888494 27863252)
Interacting Genes		15 interacting genes: ABL1 ABL2 ACKR2 CAMP CISH EBNA1BP2 FAM9B IDH2 ITGA9 MAPK6 MLH1 MST1R RHOA SELENBP1 UQCRC1	27 interacting genes: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8 CREB3 DCP2 EFNA5 GJA8 GPX1 MS4A1 NIPAL4 RHOA SACM1L SLC13A4 TMEM167B
Entrez ID		2876	1238
HPRD ID		11749	09095
Ensembl ID		ENSG00000233276	ENSG00000144648
Uniprot IDs		A0A2R8Y6B6 P07203 Q7L4Q3	A1LP82 O00590
PDB IDs		2F8A
Enriched GO Terms of Interacting Partners?
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