ACKR2 and SACM1L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ACKR2	SACM1L
Description		atypical chemokine receptor 2	SAC1 like phosphatidylinositide phosphatase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Early Endosome Cytosol Actin Filament Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle Recycling Endosome	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Endoplasmic Reticulum Membrane Endoplasmic Reticulum-plasma Membrane Contact Site
	Molecular Function	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	Phosphatidylinositol-3-phosphatase Activity Protein Binding Phosphatase Activity Phosphatidylinositol Bisphosphate Phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity
	Biological Process	Endocytosis Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Multicellular Organism Development Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Dephosphorylation
Pathways		Chemokine receptors bind chemokines	Synthesis of PIPs at the ER membrane Synthesis of PIPs at the Golgi membrane
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eotaxin levels ( 27989323) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte chemoattractant protein-1 levels ( 27989323) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Thymus and reactivation regulated chemokine levels ( 33227023) White blood cell count ( 32888494 27863252)	Acne (severe) ( 24927181) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Macular telangiectasia type 2 ( 33654266) Response to anti-depressant treatment in major depressive disorder ( 22041458) Serum metabolite levels ( 33031748) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		27 interacting genes: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8 CREB3 DCP2 EFNA5 GJA8 GPX1 MS4A1 NIPAL4 RHOA SACM1L SLC13A4 TMEM167B	35 interacting genes: ACKR2 AQP6 ARL13B CD79A COPA COPB2 COPG1 CREB3 CREB3L1 DHRS7 EBP FFAR2 FMO3 GPR151 GPR152 HSD17B13 JAGN1 LMNA MFF MFSD14B MTERF2 ODF4 PRKCA RNF19B RTN3 SCN3B SLC10A1 SLC10A6 SLC35A5 SLC35C2 SLC7A1 TMEM167B TMX2 VEZT ZFYVE27
Entrez ID		1238	22908
HPRD ID		09095	07587
Ensembl ID		ENSG00000144648	ENSG00000211456
Uniprot IDs		A1LP82 O00590	B4DVV3 E9PGZ4 Q9NTJ5
PDB IDs
Enriched GO Terms of Interacting Partners?
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