MAT2B and STC1

		MAT2B	STC1
Description		methionine adenosyltransferase 2B	stanniocalcin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Methionine Adenosyltransferase Complex Extracellular Exosome	Extracellular Space Nucleus Cytoplasm Apical Plasma Membrane
	Molecular Function	Protein Binding Enzyme Binding Methionine Adenosyltransferase Regulator Activity	Hormone Activity Protein Binding Identical Protein Binding
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Regulation Of Catalytic Activity	Ossification Endothelial Cell Morphogenesis Growth Plate Cartilage Axis Specification Cellular Calcium Ion Homeostasis Signal Transduction Embryo Implantation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Response To Vitamin D Chondrocyte Proliferation Regulation Of Anion Transport Decidualization Negative Regulation Of Calcium Ion Transport Bone Development Cellular Response To CAMP Cellular Response To Glucocorticoid Stimulus Cellular Response To Hypoxia Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Calcium Ion Import Negative Regulation Of Renal Phosphate Excretion
Pathways		Methylation Ub-specific processing proteases
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Aging ( 22773346) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Broad depression or major depressive disorder (self-reported) ( 30626913) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) General risk tolerance (MTAG) ( 30643258) Methadone dose in opioid dependence ( 28115739) Neuritic plaque ( 31497858) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Smoking initiation ( 24665060) Uterine fibroid size (maximum dimension) ( 30196971) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)	Blood osmolality (transformed sodium) ( 28360221) Blood urea nitrogen levels ( 31152163 29403010) Chronic kidney disease ( 31152163 20383146) Creatinine levels ( 31015462 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Kidney volume ( 34128465) Serum uric acid levels ( 30993211) Subcutaneous adipose tissue ( 22589738) Urate levels ( 31985003 31578528 23263486) Urinary albumin-to-creatinine ratio ( 31511532) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		16 interacting genes: APP CNIH4 FBXO25 GABRA1 HRH1 KPNA3 KPNA4 MAT2A MSX2 PLA2G6 RABEP1 STC1 TEPSIN TMED9 TRIM27 YTHDF3	3 interacting genes: MAT2B MEOX2 NOTCH1
Entrez ID		27430	6781
HPRD ID		05701	03115
Ensembl ID		ENSG00000038274	ENSG00000159167
Uniprot IDs		A0A140VJP2 Q9NZL9	P52823
PDB IDs		2YDX 2YDY 4KTT 4KTV 4NDN
Enriched GO Terms of Interacting Partners?
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