UBE2S and OTUB1

Number of citations of the paper that reports this interaction (PubMedID 20622874)
148

Data Source:
BioGRID (enzymatic study)

		UBE2S	OTUB1
Description		ubiquitin conjugating enzyme E2 S	OTU deubiquitinase, ubiquitin aldehyde binding 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Anaphase-promoting Complex Binding Ubiquitin Conjugating Enzyme Activity	Thiol-dependent Deubiquitinase Protein Binding NEDD8-specific Protease Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding
	Biological Process	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Anaphase-promoting Complex-dependent Catabolic Process Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Cell Division Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity	Adaptive Immune Response DNA Repair Cellular Response To DNA Damage Stimulus Protein K48-linked Deubiquitination Cellular Response To Interleukin-1 Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Ub-specific processing proteases Ovarian tumor domain proteases
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756)
Interacting Genes		34 interacting genes: AKT1 ANAPC1 ANAPC11 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CTNNB1 CYLD HERC1 LINC00839 MDM2 OTUB1 OTUD7B PRKN RBCK1 STAMBP UBA1 UBA6 UBB UBC UCHL3 USP2 USP21 USP5 USP7 VHL ZRANB1	58 interacting genes: ACVR1 ACVR1B ANXA1 ANXA7 AURKA BIRC2 BMPR1A BMPR1B CD274 CDKN1A CPEB2 CSNK2A1 ECT2 ESR1 FOXM1 H2AX IL1RL2 KDM1A MAPT NEDD8 PACS1 PJA1 RFFL RHOA RNF126 RNF128 SLC7A11 SMAD2 SMAD3 SMAD4 SMAD9 SNAI1 TGFBR1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBA6 UBC UBD UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2N UBE2S UBE2V2 UBE2Z UBE4B USP15 USP21 USP28
Entrez ID		27338	55611
HPRD ID		15603	08493
Ensembl ID		ENSG00000108106	ENSG00000167770
Uniprot IDs		Q16763	B3KUV5 Q96FW1
PDB IDs		1ZDN 5BNB 5L9T 6QH3 6QHK 6S96 6S98	2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT
Enriched GO Terms of Interacting Partners?
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