AMPH and AP2A2

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		AMPH	AP2A2
Description		amphiphysin	adaptor related protein complex 2 subunit alpha 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Synaptic Vesicle Membrane Leading Edge Membrane	Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Phospholipid Binding	Molecular_function Protein Binding Lipid Binding Protein Kinase Binding Clathrin Adaptor Activity Disordered Domain Specific Binding Cargo Adaptor Activity
	Biological Process	Endocytosis Chemical Synaptic Transmission Synaptic Vesicle Endocytosis	Intracellular Protein Transport Receptor-mediated Endocytosis Clathrin-dependent Endocytosis
Pathways		Clathrin-mediated endocytosis	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 30946743) Bitter non-alcoholic beverage consumption ( 31046077) Cerebral microbleeds ( 31209788) Post bronchodilator FEV1 ( 26634245)	Adult asthma ( 27611488) Alzheimer's disease ( 30636644) Alzheimer's disease (late onset) ( 24162737) Asthma ( 31959851) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581)
Interacting Genes		28 interacting genes: AP2A2 ARL16 BIN1 CABIN1 CDK1 CDK5 CDK5R1 CLTC DEUP1 DNM1 DNM2 DYRK1A ITSN2 KHDRBS1 MAPK6 MAPT NECAP1 PLD2 PPP3CA PPP3CC SH3GL2 SH3GLB1 SYN1 SYNJ1 TERF1 TTF1 UBC VTN	22 interacting genes: AAGAB AMPH AP1S1 AP2B1 APP BIN1 DNAJC6 DNM1 EPN1 EPS15 HTT ILK KCNQ1DN LRPPRC NLGN3 NUMB SHC1 SLC2A8 SMAD1 SNAP91 UBC ZPR1
Entrez ID		273	161
HPRD ID		02687	06256
Ensembl ID		ENSG00000078053	ENSG00000183020
Uniprot IDs		P49418	O94973
PDB IDs		1KY7 1UTC 3SOG 4ATM 5M5S 5M61
Enriched GO Terms of Interacting Partners?
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