GIP and SGTA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GIP	SGTA
Description		gastric inhibitory polypeptide	small glutamine rich tetratricopeptide repeat co-chaperone alpha
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Lumen Neuronal Cell Body	Nucleus Cytoplasm Cytosol Membrane TRC Complex Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Hormone Activity Protein Binding Gastric Inhibitory Polypeptide Receptor Binding Glucagon Receptor Binding	Protein Binding Identical Protein Binding Protein Self-association Molecular Adaptor Activity BAT3 Complex Binding
	Biological Process	Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Female Pregnancy Memory Adult Locomotory Behavior Response To Xenobiotic Stimulus Response To Glucose Response To Selenium Ion Response To Acidic PH Positive Regulation Of Glucose Transmembrane Transport Response To Organic Cyclic Compound Sensory Perception Of Pain Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Response To Lipid Exploration Behavior Gastric Inhibitory Peptide Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Response To Starvation Response To Amino Acid Response To Peptide Hormone Positive Regulation Of CAMP-mediated Signaling Response To Axon Injury Regulation Of Insulin Secretion Digestive System Development Long-term Synaptic Potentiation Positive Regulation Of Glucagon Secretion Triglyceride Homeostasis	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Ubiquitin-dependent ERAD Pathway Chaperone-mediated Protein Folding Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chaperone-mediated Protein Folding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Automobile speeding propensity ( 30643258) Blood glucose levels ( 31928498) Coronary artery disease ( 29212778) Coronary heart disease ( 21378990) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Household income ( 31844048) Liver enzyme levels (alkaline phosphatase) ( 33972514) Systolic blood pressure ( 31928498 30578418) Type 2 diabetes ( 28566273 29358691) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		6 interacting genes: ADAMTSL4 GIPR KRTAP10-3 NOTCH2NLA SGTA SGTB	176 interacting genes: ADAM21 ADIPOQ ADRM1 AGR2 AGR3 AOC3 BAG6 BCL2L12 BTC C1QA C1QL4 C1QTNF1 C1QTNF5 C1QTNF6 C3orf52 C5orf46 CD79B CD99 CD99L2 CDH15 CDSN CHRNG COL1A2 COL8A2 CREB3L3 CSF1 CST1 CTAG1A CTAG1B CTSL CXCL8 CYB5R1 DEFB131A DKK3 DMKN EDA2R EDAR EFEMP1 EFEMP2 ERP27 ERP29 ETNK1 EVA1B F11R FERD3L FGF21 FIP1L1 FKBP7 FSTL1 FXYD2 FXYD7 FZD7 GABARAPL2 GAL GALP GHR GIP GPX7 GRN GUCA2A GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA4 HSPA8 IER3 IGFBP6 IGL IGLC1 IL6ST IRF3 IRF5 ITPRIPL1 KASH5 KCNA1 KCNA10 KCNE5 KRT6A KTN1 LAIR2 LAT LCN2 LDLRAD4 LSMEM2 MRAP2 MS4A3 MSMB MSTN MYDGF MYOC NAXD NME3 NPVF NR3C1 NRSN2 NXF1 PAGE3 PBXIP1 PCDHA4 PCDHGA4 PFN2 PGLYRP2 PGR PIAS1 PLAAT4 PMEPA1 PPIB PPIC PPP1R3C PRAP1 PRB4 PRRG2 PSORS1C2 PTN PYY RCN1 RNASE10 RNF144A RNF144B RNF170 RPN1 SDC4 SDF2L1 SERPINE1 SERPINI2 SGCA SGTB SHISA4 SHISA5 SLPI SMAGP SMIM14 SMIM5 SOD3 SPINK9 SPN SPP1 SPPL2A SRGN SRL STMP1 SUOX SYT11 SYT4 TFF3 TFRC TGFA TMEM154 TMEM174 TMEM230 TMEM31 TMEM98 TMPO TMPRSS11D TMUB2 TNFRSF10C TNFRSF13B TNFRSF19 TNFRSF1A TNFRSF21 TNFSF12 TRIM5 TWSG1 TXNDC12 UBL4A UBQLN2 UPK3A VIP WBP1L WFDC12 WFDC13 WFDC5 ZBTB8B ZG16 ZG16B
Entrez ID		2695	6449
HPRD ID		15925	04568
Ensembl ID		ENSG00000159224	ENSG00000104969
Uniprot IDs		P09681	O43765
PDB IDs		1T5Q 2B4N 2L70 2L71 2OBU 2QKH	2VYI 4CPG 4GOD 4GOE 4GOF
Enriched GO Terms of Interacting Partners?
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