GIP and GIPR

Number of citations of the paper that reports this interaction (PubMedID 15655707)
14

Data Source:
HPRD (in vivo)

		GIP	GIPR
Description		gastric inhibitory polypeptide	gastric inhibitory polypeptide receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Lumen Neuronal Cell Body	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Hormone Activity Protein Binding Gastric Inhibitory Polypeptide Receptor Binding Glucagon Receptor Binding	Transmembrane Signaling Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Gastric Inhibitory Peptide Receptor Activity Peptide Hormone Binding Glucagon Family Peptide Binding
	Biological Process	Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Female Pregnancy Memory Adult Locomotory Behavior Response To Xenobiotic Stimulus Response To Glucose Response To Selenium Ion Response To Acidic PH Positive Regulation Of Glucose Transmembrane Transport Response To Organic Cyclic Compound Sensory Perception Of Pain Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Response To Lipid Exploration Behavior Gastric Inhibitory Peptide Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Response To Starvation Response To Amino Acid Response To Peptide Hormone Positive Regulation Of CAMP-mediated Signaling Response To Axon Injury Regulation Of Insulin Secretion Digestive System Development Long-term Synaptic Potentiation Positive Regulation Of Glucagon Secretion Triglyceride Homeostasis	Desensitization Of G Protein-coupled Receptor Signaling Pathway Generation Of Precursor Metabolites And Energy Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Response To Glucose Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Gastric Inhibitory Peptide Signaling Pathway Positive Regulation Of CAMP-mediated Signaling Response To Axon Injury Regulation Of Insulin Secretion Response To Calcium Ion Response To Fatty Acid
Pathways		Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Automobile speeding propensity ( 30643258) Blood glucose levels ( 31928498) Coronary artery disease ( 29212778) Coronary heart disease ( 21378990) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Household income ( 31844048) Liver enzyme levels (alkaline phosphatase) ( 33972514) Systolic blood pressure ( 31928498 30578418) Type 2 diabetes ( 28566273 29358691) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference adjusted for body mass index ( 34021172)	Adult body size ( 32376654) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 22344219 29381148 24861553 31453325 28892062 20935630 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Breast cancer ( 29059683) Fasting glucose ( 33402679) Fruit consumption ( 32066663) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) GIP levels in response to oral glucose tolerance test (fasting) ( 29093273) Glycated hemoglobin levels ( 34059833) Hemoglobin A1c levels ( 29403010) Hip circumference ( 31453325 25673412) Hip circumference variance ( 31453325) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Left ventricular end-diastolic volume (MTAG) ( 33495596) Left ventricular end-systolic volume (MTAG) ( 33495596) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Obesity ( 23563607) Pancreatic beta-cell glucose sensitivity ( 32944759) Pulse pressure ( 30224653) Subcutaneous adipose tissue ( 22589738) Systolic blood pressure ( 30578418) Two-hour glucose ( 34059833) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 26818947 32499647 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Urinary potassium to creatinine ratio ( 30910378) Waist circumference ( 31453325) Waist circumference variance ( 31453325)
Interacting Genes		6 interacting genes: ADAMTSL4 GIPR KRTAP10-3 NOTCH2NLA SGTA SGTB	2 interacting genes: GIP LNX1
Entrez ID		2695	2696
HPRD ID		15925	00670
Ensembl ID		ENSG00000159224	ENSG00000010310
Uniprot IDs		P09681	P48546
PDB IDs		1T5Q 2B4N 2L70 2L71 2OBU 2QKH	2QKH 4HJ0 6DKJ
Enriched GO Terms of Interacting Partners?
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