GC and ACTA2

Number of citations of the paper that reports this interaction (PubMedID 12119014)
13

Data Source:
HPRD (in vitro)

		GC	ACTA2
Description		GC vitamin D binding protein	actin alpha 2, smooth muscle
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Lysosomal Lumen Extracellular Exosome Blood Microparticle	Extracellular Space Cytoplasm Cytosol Dynactin Complex Lamellipodium Filopodium Smooth Muscle Contractile Fiber Protein-containing Complex Cell Body Extracellular Exosome
	Molecular Function	Actin Binding Vitamin D Binding Vitamin Transmembrane Transporter Activity Calcidiol Binding	ATP Binding Protein Kinase Binding
	Biological Process	Transport Vitamin Transmembrane Transport Vitamin D Metabolic Process Vitamin Transport	Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Glomerular Mesangial Cell Development Mesenchyme Migration
Pathways		Vitamin D (calciferol) metabolism	Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription
Drugs		Vitamin D	Phenethyl Isothiocyanate
Diseases
GWAS		Blood protein levels ( 29875488) Granulocyte count ( 27863252) Lymphocyte counts ( 32888494) Metabolite levels ( 22916037) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Neutrophil count ( 32888494 27863252) Non-alcoholic fatty liver disease histology (other) ( 23213074) Platelet count ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278) Serum 25-Hydroxyvitamin D levels ( 33382404 29545823 29325163 31841498) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum vitamin D-binding protein levels ( 24740207) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Vitamin D insufficiency ( 20541252) Vitamin D levels ( 29343764 22673963 20418485 25208829) Vitamin D levels (dietary vitamin D intake interaction) ( 29343764) White blood cell count ( 32888494 27863252)	Arthritis (juvenile idiopathic) ( 33106285) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 26956414 23770605) Immunoglobulin A ( 20694011) Lymphocyte percentage of white cells ( 32888494) Pulse pressure ( 30578418) Selective IgA deficiency ( 27723758)
Interacting Genes		14 interacting genes: ACTA1 ACTA2 ACTC1 C3 CCND3 CDC73 CUBN GRB2 HSP90AA1 LRIF1 LRP2 PIK3R3 SERF2 SLC9A3R1	18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1
Entrez ID		2638	59
HPRD ID		00749	00031
Ensembl ID		ENSG00000145321	ENSG00000107796
Uniprot IDs		P02774	D2JYH4 P62736
PDB IDs		1J78 1J7E 1KW2 1KXP 1LOT 1MA9
Enriched GO Terms of Interacting Partners?
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