APPL1 and CTTNBP2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
13

Data Source:
BioGRID (two hybrid)

		APPL1	CTTNBP2
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	cortactin binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Macropinosome Extracellular Exosome Intracellular Vesicle	Cell Cortex Synaptic Vesicle Dendritic Spine Postsynaptic Actin Cytoskeleton Glutamatergic Synapse
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding	Protein Binding SH3 Domain Binding
	Biological Process	Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Glucose Import Positive Regulation Of Glucose Import Positive Regulation Of Melanin Biosynthetic Process Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Brain Development Regulation Of Modification Of Postsynaptic Actin Cytoskeleton
Pathways		Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) General factor of neuroticism ( 30867560) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 33627673 29891935) Idiopathic osteonecrosis of the femoral head ( 28000841) Intraocular pressure ( 29617998 29785010 31959993 30054594) Myocardial infarction ( 33532862) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (current vs never) ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Sociability score ( 34054130) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 30108155) Type 2 diabetes ( 30054458 30297969) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Worry too long after an embarrassing experience ( 34054130)
Interacting Genes		65 interacting genes: ADI1 ADIPOR1 ADIPOR2 AGL AKT1 AKT2 ANKRD1 APPL2 ATP2A1 BATF3 BIN1 BRWD1 C1QTNF9 CBL CBLB CIPC CMTM4 CTTNBP2 DACT1 DCC DNM2 DOK2 DOK3 DOK7 DPYSL5 DTNA DYSF EGFR FARS2 FSHR GPC3 HDAC2 HSPB1 ID1 IMPDH2 INO80E KLF15 KXD1 LUC7L MAGEA9 MAGEC3 MAP3K1 MEOX1 MTA2 MYCBP2 MYH3 PIK3CA PIK3R1 PIK3R2 PLEKHF2 PNMA5 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 SCAPER SH2D2A SOCS6 SPART TP53 TP53BP2 TRAF2 UBE2O ZNF829	11 interacting genes: APPL1 ARNTL2 CTTN FAM86C1P HSF2BP IMMP2L INCA1 KRT14 MAGEA11 MEI4 PKNOX2
Entrez ID		26060	83992
HPRD ID		05053	09890
Ensembl ID		ENSG00000157500	ENSG00000077063
Uniprot IDs		Q9UKG1	Q20BG9 Q8WZ74
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B
Enriched GO Terms of Interacting Partners?
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