APPL1 and RHEBL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		APPL1	RHEBL1
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	RHEB like 1
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Macropinosome Extracellular Exosome Intracellular Vesicle	Cytoplasm Plasma Membrane Endomembrane System
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Metal Ion Binding
	Biological Process	Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Glucose Import Positive Regulation Of Glucose Import Positive Regulation Of Melanin Biosynthetic Process Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Small GTPase Mediated Signal Transduction TOR Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases
GWAS			Bipolar disorder ( 28115744 33263727 31043756) Reaction time ( 29844566)
Interacting Genes		65 interacting genes: ADI1 ADIPOR1 ADIPOR2 AGL AKT1 AKT2 ANKRD1 APPL2 ATP2A1 BATF3 BIN1 BRWD1 C1QTNF9 CBL CBLB CIPC CMTM4 CTTNBP2 DACT1 DCC DNM2 DOK2 DOK3 DOK7 DPYSL5 DTNA DYSF EGFR FARS2 FSHR GPC3 HDAC2 HSPB1 ID1 IMPDH2 INO80E KLF15 KXD1 LUC7L MAGEA9 MAGEC3 MAP3K1 MEOX1 MTA2 MYCBP2 MYH3 PIK3CA PIK3R1 PIK3R2 PLEKHF2 PNMA5 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 SCAPER SH2D2A SOCS6 SPART TP53 TP53BP2 TRAF2 UBE2O ZNF829	14 interacting genes: ACVR1 AKT1 APPL1 BMPR1B CCDC65 EIF4EBP1 FHL3 MTOR PRKAB2 SMAD1 SMAD2 SMAD4 TGFBR1 TXNL4A
Entrez ID		26060	121268
HPRD ID		05053	15245
Ensembl ID		ENSG00000157500	ENSG00000167550
Uniprot IDs		Q9UKG1	Q8TAI7
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B	3OES
Enriched GO Terms of Interacting Partners?
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