GABRR1 and P2RX2

Number of citations of the paper that reports this interaction (PubMedID 14660627)
23

Data Source:
HPRD (in vivo, in vitro)

		GABRR1	P2RX2
Description		gamma-aminobutyric acid type A receptor subunit rho1	purinergic receptor P2X 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Chloride Channel Complex Neuron Projection Synapse Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse GABA-A Receptor Complex	Integral Component Of Nuclear Inner Membrane Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Neuronal Cell Body Receptor Complex Postsynapse
	Molecular Function	GABA-A Receptor Activity Chloride Channel Activity Neurotransmitter Receptor Activity Ligand-gated Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity ATP Binding Ligand-gated Ion Channel Activity Identical Protein Binding
	Biological Process	Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Regulation Of Postsynaptic Membrane Potential Regulation Of Presynaptic Membrane Potential Chloride Transmembrane Transport	Response To Hypoxia Response To Ischemia Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Neuromuscular Synaptic Transmission Neuromuscular Junction Development Sensory Perception Of Sound Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Peristalsis Response To ATP Purinergic Nucleotide Receptor Signaling Pathway Behavioral Response To Pain Skeletal Muscle Fiber Development Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Excitatory Postsynaptic Potential Cation Transmembrane Transport
Pathways		GABA receptor activation	Elevation of cytosolic Ca2+ levels Platelet homeostasis
Drugs		Lindane Picrotoxin Fludiazepam	Promethazine
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Bipolar disorder and schizophrenia ( 20889312) Diabetic kidney disease in type 2 diabetes ( 29703844) Early diabetic kidney disease in type 2 diabetes ( 29703844) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472)	Body mass index ( 26426971) Fasting glucose ( 33402679)
Interacting Genes		10 interacting genes: CSNK2A1 GABRR2 MAP1B MAPK1 P2RX2 PRKACA PRKCA PRKG1 SLC6A9 SQSTM1	3 interacting genes: GABRR1 P2RX1 P2RX3
Entrez ID		2569	22953
HPRD ID		15921	15984
Ensembl ID		ENSG00000146276	ENSG00000187848
Uniprot IDs		P24046	Q32MC3 Q9UBL9
PDB IDs
Enriched GO Terms of Interacting Partners?
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